Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial

• Published in: Current controlled trials in cardiovascular medicine Vol. 22; no. 1; p. 642
• Main Authors: Yaqub, Sheraz, Bjarnbeth, Bjarn Atle, Angelsen, Jon-Helge, Fristrup, Claus Wilki, Granbech, Jon Erik, Hemmingsson, Oskar, Isaksson, Bengt, Juel, Ingebjarg Soterud, Larsen, Peter Nargaard, Lindell, Gert, Mortensen, Frank Viborg, Mortensen, Kim Erlend, Rizell, Magnus, Sandström, Per, Sandvik, Oddvar Mathias, Sparrelid, Ernesto, Taflin, Helena, Taskén, Kjetil, Brudvik, Kristoffer W, Fretland, Ãsmund A, Horn, Arild, Kleive, Dyre, Labori, Knut J, Lassen, Kristoffer, Rasok, Bård I, Sareide, Jon A, Tholfsen, Tore, Villanger, Olaug, Waage, Anne
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 20.09.2021; BioMed Central; BMC
• Subjects: Acetylsalicylic acid; adenomas; Antigens; antitumor immune-responses; Apoptosis; Aspirin; Cancer and Oncology; Cancer och onkologi; Cancer therapies; Care and treatment; Clinical medicine; Colorectal cancer; cyclooxygenase-2; Diagnosis; Diseases; follow-up; Gastrointestinal surgery; Hospitals; inhibition; Kinases; Kirurgi; Klinisk medicin; Liver; Liver metastases; Lymphocytes; Medical research; Medicin och hälsovetenskap; Medicine; Metastasis; Mortality; Mutation; Patient outcomes; pik3ca mutation; Prevention; regulatory t-cells; Relapse; Research & Experimental Medicine; Secondary prevention; Study Protocol; suppression; Surgery; Testing; Tumors; Norway; Denmark; Sweden; Aarhus Denmark; Secondary prevention; Aspirin; Liver metastases; Acetylsalicylic acid; Colorectal cancer
• ISSN: 1745-6215; 1745-6215
• DOI: 10.1186/s13063-021-05587-w

Abstract Background Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM). Up to 800 patients operated for CRCLM will be randomized to Arm#1 ASA 160 mg once daily or Arm#2 Placebo, for a period of 3 years or until disease recurrence. The patients will be recruited at all major hepatobiliary surgical units in Norway, Sweden and Denmark and have follow-up according to standard of care and the National Guidelines. Discussion The ASAC trial will be the first clinical interventional trial to assess the potential beneficial role of ASA in recurrence of CRCLM and survival. ASA is an inexpensive, well-tolerated and easily accessible drug that will be highly potential as adjuvant drug in secondary prevention of CRCLM if the study shows a beneficial effect. We will also determine the effect of ASA as adjuvant treatment on Health-Related Quality of Life and the cost-effectiveness. Trial registration ClinicalTrials.gov NCT03326791. Registered on 31 October 2017.