A cohort study on the association between changing occupational stress, hair cortisol concentration, and hypertension

• Published in: PloS one Vol. 18; no. 5; p. e0285623
• Main Authors: Wang, Jin, Zhu, Lejia, Song, Lin, Zhou, Ziqi, Chan, Weiling, Li, Geyang, Zhou, Li, Xiao, Jing, Lian, Yulong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.05.2023; Public Library of Science (PLoS)
• Subjects: Adrenocortical Hyperfunction; Adult; Biology and Life Sciences; Blood pressure; Bus drivers; Cardiovascular disease; Circadian rhythm; Cohort analysis; Cohort Studies; Complications and side effects; Corticosteroids; Cortisol; Cross-sectional studies; Diagnosis; Exercise; Hair; Hormones; Humans; Hydrocortisone; Hypertension; Hypertension - epidemiology; Hypertension - etiology; Job stress; Male; Medicine and Health Sciences; Middle Aged; Occupational health; Occupational stress; Occupational Stress - complications; Occupations; Pressure effects; Properties; Psychological stress; Questionnaires; Risk factors; Social Sciences; Stress; Stress concentration; Stress, Psychological - complications; Urine; Workers; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0285623

To explore the relationship between changing occupational stress levels, hair cortisol concentration (HCC), and hypertension. Baseline blood pressure of 2520 workers was measured in 2015. The Occupational Stress Inventory-Revised Edition (OSI-R) was used to assess changes in occupational stress. Occupational stress and blood pressure were followed up annually from January 2016 to December 2017. The final cohort numbered 1784 workers. The mean age of the cohort was 37.77±7.53 years and the percentage male was 46.52%. At baseline, 423 eligible subjects were randomly selected for hair sample collection to determine cortisol levels. Increased occupational stress was a risk factor for hypertension [risk ratio (RR) = 4.200, 95% confidence interval (CI): 1.734-10.172]. The HCC of workers with elevated occupational stress was higher than that of workers with constant occupational stress [(ORQ score ≥70: geometric mean±geometric standard deviation = 5.25±3.59 ng/g hair; 60-90: 5.02±4.00; 40-59: 3.45±3.41; <40: 2.73±3.40) x2 = 5.261]. High HCC increased the risk of hypertension (RR = 5.270, 95% CI: 2.375-11.692) and high HCC was associated with higher rates of elevated diastolic and systolic blood pressure. The mediating effect of HCC was 0.51[(95% CI: 0.23-0.79, odds ratio(OR) = 1.67] and accounted for 36.83% of the total effect. Increased occupational stress could lead to an increase in hypertension incidence. High HCC could increase the risk of hypertension. HCC acts as a mediator between occupational stress and hypertension.