Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease

• Published in: PloS one Vol. 8; no. 11; p. e81233
• Main Authors: Bolitho, Samuel J, Naismith, Sharon L, Salahuddin, Pierre, Terpening, Zoe, Grunstein, Ron R, Lewis, Simon J G
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.11.2013; Public Library of Science (PLoS)
• Subjects: Actigraphy; Affect; Age; Aged; Aging; Attention; Brain research; Case-Control Studies; Cognition; Cognition & reasoning; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Cognitive ability; Cognitive disorders; Daytime; Fatigue; Female; Humans; Information processing; Kinases; Male; Measurement; Measuring techniques; Medical research; Middle Aged; Morbidity; Movement disorders; Neurodegenerative diseases; Neuropsychological Tests; Neurosciences; Older people; Parkinson Disease - complications; Parkinson Disease - drug therapy; Parkinson's disease; Patients; Pharmacology; Psychology; Sleep; Sleep and wakefulness; Sleep deprivation; Sleep disorders; Sleep Wake Disorders - diagnosis; Sleep Wake Disorders - etiology; Sleepiness; Studies; Wrist
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0081233

Sleep-wake disturbances and concomitant cognitive dysfunction in Parkinson's disease (PD) contribute significantly to morbidity in patients and their carers. Subjectively reported daytime sleep disturbance is observed in over half of all patients with PD and has been linked to executive cognitive dysfunction. The current study used daytime actigraphy, a novel objective measure of napping and related this to neuropsychological performance in a sample of PD patients and healthy, age and gender-matched controls. Furthermore this study aimed to identify patients with PD who may benefit from pharmacologic and behavioural intervention to improve these symptoms. Eighty-five PD patients and 21 healthy, age-matched controls completed 14 days of wrist actigraphy within two weeks of neuropsychological testing. Objective napping measures were derived from actigraphy using a standardised protocol and subjective daytime sleepiness was recorded by the previously validated Epworth Sleepiness Scale. Patients with PD had a 225% increase in the mean nap time per day (minutes) as recorded by actigraphy compared to age matched controls (39.2 ± 35.2 vs. 11.5 ± 11.0 minutes respectively, p < 0.001). Significantly, differences in napping duration between patients, as recorded by actigraphy were not distinguished by their ratings on the subjective measurement of excessive daytime sleepiness. Finally, those patients with excessive daytime napping showed greater cognitive deficits in the domains of attention, semantic verbal fluency and processing speed. This study confirms increased levels of napping in PD, a finding that is concordant with subjective reports. However, subjective self-report measures of excessive daytime sleepiness do not robustly identify excessive napping in PD. Fronto-subcortical cognitive dysfunction was observed in those patients who napped excessively. Furthermore, this study suggests that daytime actigraphy, a non-invasive and inexpensive objective measure of daytime sleep, can identify patients with PD who may benefit from pharmacologic and behavioural interventions to improve these symptoms.