Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice

• Published in: PloS one Vol. 9; no. 1; p. e86416
• Main Authors: Kikuchi, Yosuke, Kunitoh-Asari, Ayami, Hayakawa, Katsuyuki, Imai, Shinjiro, Kasuya, Kenji, Abe, Kimio, Adachi, Yu, Fukudome, Shin-ichi, Takahashi, Yoshimasa, Hachimura, Satoshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.01.2014; Public Library of Science (PLoS)
• Subjects: Acids; Administration, Oral; Animals; B cells; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Bacteria; Biology; Cytokines; Cytokines - biosynthesis; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Female; Gene Expression; Growth factors; Health aspects; Immune system; Immunoglobulin A; Immunoglobulin A, Secretory - immunology; Immunoglobulins; Immunology; Immunoregulation; Infections; Infectious diseases; Influenza; Influenza viruses; Interleukin 6; Intestine, Small - immunology; Lactic acid; Lactic acid bacteria; Lactobacillus plantarum; Lactobacillus plantarum - immunology; Lungs; Lymphocytes B; Medicine; Mice; Mucosal immunity; Oral administration; Orthomyxoviridae - immunology; Orthomyxoviridae Infections - genetics; Orthomyxoviridae Infections - immunology; Orthomyxoviridae Infections - prevention & control; Peyer's Patches - cytology; Peyer's Patches - immunology; Plant protection; Plasma cells; Probiotics; Probiotics - administration & dosage; Quality control; R&D; Research & development; Rodents; Science; Small intestine; Survival; Viruses; Yeast; Japan

The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA pro...