Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice

The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA pro...

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Published inPloS one Vol. 9; no. 1; p. e86416
Main Authors Kikuchi, Yosuke, Kunitoh-Asari, Ayami, Hayakawa, Katsuyuki, Imai, Shinjiro, Kasuya, Kenji, Abe, Kimio, Adachi, Yu, Fukudome, Shin-ichi, Takahashi, Yoshimasa, Hachimura, Satoshi
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 22.01.2014
Public Library of Science (PLoS)
Subjects
Acids
Administration, Oral
Animals
B cells
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Bacteria
Biology
Cytokines
Cytokines - biosynthesis
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Female
Gene Expression
Growth factors
Health aspects
Immune system
Immunoglobulin A
Immunoglobulin A, Secretory - immunology
Immunoglobulins
Immunology
Immunoregulation
Infections
Infectious diseases
Influenza
Influenza viruses
Interleukin 6
Intestine, Small - immunology
Lactic acid
Lactic acid bacteria
Lactobacillus plantarum
Lactobacillus plantarum - immunology
Lungs
Lymphocytes B
Medicine
Mice
Mucosal immunity
Oral administration
Orthomyxoviridae - immunology
Orthomyxoviridae Infections - genetics
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Peyer's Patches - cytology
Peyer's Patches - immunology
Plant protection
Plasma cells
Probiotics
Probiotics - administration & dosage
Quality control
R&D
Research & development
Rodents
Science
Small intestine
Survival
Viruses
Yeast
Japan
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Abstract The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer's patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer's patch dendritic cells, with this production promoting IgA(+) B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.
AbstractList The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer’s patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer’s patch dendritic cells, with this production promoting IgA+ B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.
The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer’s patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer’s patch dendritic cells, with this production promoting IgA + B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.
The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer's patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer's patch dendritic cells, with this production promoting IgA.sup.+ B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.
The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer's patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer's patch dendritic cells, with this production promoting IgA(+) B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer's patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer's patch dendritic cells, with this production promoting IgA(+) B cells to differentiate into IgA-secreting plasma cells. We also observed that oral administration of L. plantarum AYA in mice caused an increase in IgA production in the small intestine and lung. This production of IgA correlated strongly with protective ability, with the treated mice surviving longer than the control mice after lethal influenza virus infection. Our data therefore reveals a novel immunoregulatory role of the L. plantarum AYA strain which enhances mucosal IgA production and provides protection against respiratory influenza virus infection.
Audience Academic
Author Abe, Kimio
Takahashi, Yoshimasa
Adachi, Yu
Kasuya, Kenji
Hayakawa, Katsuyuki
Kikuchi, Yosuke
Kunitoh-Asari, Ayami
Hachimura, Satoshi
Fukudome, Shin-ichi
Imai, Shinjiro
AuthorAffiliation 4 Laboratory of Yeast and Fermentation Food Division, Oriental Yeast Co., Ltd., Itabashi-ku, Tokyo, Japan
6 Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan
2 Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka-city, Shizuoka, Japan
3 Yeast Function Development Unit, Oriental Yeast Co., Ltd., Itabashi-ku, Tokyo Japan
Virginia Tech University, United States of America
1 Research Center for Basic Science, Research and Development, Quality Assurance Division, Nisshin Seifun Group Inc., Fujimino-city, Saitama, Japan
5 Department of Immunology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan
AuthorAffiliation_xml – name: 1 Research Center for Basic Science, Research and Development, Quality Assurance Division, Nisshin Seifun Group Inc., Fujimino-city, Saitama, Japan
– name: 5 Department of Immunology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan
– name: 3 Yeast Function Development Unit, Oriental Yeast Co., Ltd., Itabashi-ku, Tokyo Japan
– name: Virginia Tech University, United States of America
– name: 4 Laboratory of Yeast and Fermentation Food Division, Oriental Yeast Co., Ltd., Itabashi-ku, Tokyo, Japan
– name: 2 Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka-city, Shizuoka, Japan
– name: 6 Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo, Japan
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  surname: Kikuchi
  fullname: Kikuchi, Yosuke
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  surname: Kunitoh-Asari
  fullname: Kunitoh-Asari, Ayami
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– sequence: 10
  givenname: Satoshi
  surname: Hachimura
  fullname: Hachimura, Satoshi
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24466081$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright COPYRIGHT 2014 Public Library of Science
2014 Kikuchi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2014 Kikuchi et al 2014 Kikuchi et al
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Competing Interests: Five authors are employed by Nisshin Seifun Group Inc., and two authors are employed by Oriental Yeast Co., Ltd. Dr. Hachimura, and Ms. Kunitoh-Asari, and Dr. Hayakawa have applied for patents for ‘effect of Lactobacillus plantarum AYA intake to enhances IgA secretion (P2008-201708A)’, and Dr. Hachimura, Mr. Kikuchi, Dr. Fukudome, Mr. Abe, and Mr. Kasuya have applied for patents for ‘effect of L.plantarum AYA intake to prevent influenza virus infection (P2013-53089A)’. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: YK AA KH SI SF YT SH. Performed the experiments: YK AA KK KA YA YT. Analyzed the data: YK AA YT SH. Contributed reagents/materials/analysis tools: KK KA YT SH. Wrote the paper: YK SI YT SH.
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Snippet The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large...
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SubjectTerms Acids
Administration, Oral
Animals
B cells
B-Lymphocytes - immunology
B-Lymphocytes - metabolism
Bacteria
Biology
Cytokines
Cytokines - biosynthesis
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Female
Gene Expression
Growth factors
Health aspects
Immune system
Immunoglobulin A
Immunoglobulin A, Secretory - immunology
Immunoglobulins
Immunology
Immunoregulation
Infections
Infectious diseases
Influenza
Influenza viruses
Interleukin 6
Intestine, Small - immunology
Lactic acid
Lactic acid bacteria
Lactobacillus plantarum
Lactobacillus plantarum - immunology
Lungs
Lymphocytes B
Medicine
Mice
Mucosal immunity
Oral administration
Orthomyxoviridae - immunology
Orthomyxoviridae Infections - genetics
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Peyer's Patches - cytology
Peyer's Patches - immunology
Plant protection
Plasma cells
Probiotics
Probiotics - administration & dosage
Quality control
R&D
Research & development
Rodents
Science
Small intestine
Survival
Viruses
Yeast
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Title Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice
URI https://www.ncbi.nlm.nih.gov/pubmed/24466081
https://www.proquest.com/docview/1491119223
https://www.proquest.com/docview/1492689149
https://pubmed.ncbi.nlm.nih.gov/PMC3899257
https://doaj.org/article/9201d556893f4e8e9f4bff5258e0ad9e
http://dx.doi.org/10.1371/journal.pone.0086416
Volume 9
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