Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement

• Published in: PloS one Vol. 7; no. 8; p. e44014
• Main Authors: Kemp, Andrew H, Quintana, Daniel S, Kuhnert, Rebecca-Lee, Griffiths, Kristi, Hickie, Ian B, Guastella, Adam J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2012; Public Library of Science (PLoS)
• Subjects: Adult; Anxieties; Anxiety; Behavior; Bioindicators; Biology; Biomarkers; Brain research; Cardiovascular diseases; Cognition & reasoning; Comorbidity; Comparative analysis; Cross-Over Studies; Design standards; Diabetes mellitus; Disease control; EKG; Electrocardiography; Experimental design; Genetic aspects; Heart rate; Heart Rate - drug effects; Human behavior; Humans; Hypotheses; Male; Medical imaging; Medicine; Mental depression; Mood; Motivation; Nervous system; Oxytocin; Oxytocin - pharmacology; Physiological aspects; Psychiatry; Scaling; Smoking; Social and Behavioral Sciences; Social Behavior; Social isolation; Studies; Time series; Variability; Australia; New South Wales Australia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0044014

Oxytocin (OT) plays a key regulatory role in human social behaviour. While prior studies have examined the effects of OT on observable social behaviours, studies have seldom examined the effects of OT on psychophysiological markers such as heart rate variability (HRV), which provides an index of individual's motivation for social behaviour. Furthermore, no studies have examined the impact of OT on HRV under resting conditions, which provides an index of maximal capacity for social engagement. To examine the effects of OT on HRV measures in healthy male participants while at rest. OT was hypothesised to increase HRV, compared to placebo, and that the effects would be greatest for a non-linear measure of HRV (the detrended fluctuation scaling exponent). Twenty-one male participants were recruited for this study. Participants were non-smokers, not on any medications and reported no history of psychiatric illness, neurological disorder, or any other serious medical condition (e.g. diabetes, cardiovascular disease). The study employed a randomised, placebo-controlled, within-subject, crossover, experimental design. HRV was calculated from electrocardiography under a standardized, 10-minute, resting state condition. As hypothesised, OT increased HRV and these effects were largest using the detrended fluctuation scaling exponent, a non-linear measure. These changes were observed in the absence of any change in state mood, as measured by the profile of mood states. Importantly, participants were unable to correctly guess which treatment they had been assigned at either of the two assessments. Together with the broader literature on OT and HRV, findings suggest that acute administration of OT may facilitate a fundamental psychophysiological feature of social behaviour, increasing capacity for social engagement. Findings also suggest that HRV changes may provide a novel biomarker of response to OT nasal spray that can be incorporated into research on response to treatment.