What Kind of Capsule Endoscope Is Suitable for a Controllable Self-Propelling Capsule Endoscope? Experimental Study Using a Porcine Stomach Model for Clinical Application (with Videos)

• Published in: PloS one Vol. 10; no. 10; p. e0139878
• Main Authors: Ota, Kazuhiro, Nouda, Sadaharu, Takeuchi, Toshihisa, Iguchi, Munetaka, Kojima, Yuichi, Kuramoto, Takanori, Inoue, Takuya, Shindo, Yasunori, Uesugi, Kenshiro, Fujito, Yoshiaki, Nishihara, Hironori, Ohtsuka, Naotake, Higuchi, Kazuhide
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.10.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Bowel disease; Buttons; Capsule Endoscopy - instrumentation; Capsule Endoscopy - methods; Care and treatment; Clinical medicine; Comparative analysis; Controllability; Critical point; Endoscopes; Endoscopy; Esophagus; Gastrointestinal endoscopy; Internal medicine; Lesions; Magnetic Fields; Medical research; Medicine; Models, Biological; Peristalsis; Risk factors; Small intestine; Stability; Stomach; Stomach - pathology; Stomach diseases; Swine; Videotape Recording; Japan; Israel
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0139878

We have been developing the Self-Propelling Capsule Endoscope (SPCE) that allows for controllability from outside of the body and real-time observation. What kind of capsule endoscope (CE) is suitable for a controllable SPCE is unclear and a very critical point for clinical application. We compared observing ability of three kinds of SPCEs with different viewing angles and frame rates. Eleven buttons were sewed in an excised porcine stomach. Four examiners controlled the SPCE using PillCamSB2, -ESO2, and -COLON2 (Given Imaging Ltd., Israel), for 10 minutes each with the aim of detecting as many buttons and examining them as closely as possible. The ability to find lesions was assessed based on the number of detected buttons. The SPCE-performance score (SPS) was used to evaluate the ability to examine the lesions in detail. The SPCE-ESO2, -COLON2, and -SB2 detected 11 [interquartile range (IQR): 0], 10.5 (IQR, 0.5), and 8 (IQR, 1.0) buttons, respectively. The SPCE-ESO2 and -COLON2 had a significantly better ability to detect lesions than the -SB2 (p < 0.05). The SPCE-ESO2, -COLON2, and -SB2 had significantly different SPS values of 22 (IQR, 0), 16.5 (IQR, 1.5), and 14 (IQR, 1.0), respectively (p < 0.05 for all comparisons; SPCE-SB2 vs. -ESO2, -SB2 vs. -COLON2, and -ESO2 vs. -COLON2). PillCamESO2 is most suitable in different three CEs for SPCE for examining lesions in detail of the stomach.