Comparison of Macular Integrity Assessment (MAIA ™), MP-3, and the Humphrey Field Analyzer in the Evaluation of the Relationship between the Structure and Function of the Macula

• Published in: PloS one Vol. 11; no. 3; p. e0151000
• Main Authors: Hirooka, Kazuyuki, Misaki, Kana, Nitta, Eri, Ukegawa, Kaori, Sato, Shino, Tsujikawa, Akitaka
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.03.2016; Public Library of Science (PLoS)
• Subjects: Aged; Biology and Life Sciences; Correlation; Correlation analysis; Defects; Engineering and Technology; Eye movements; Female; Glaucoma; Glaucoma - pathology; Humans; Integrity; Macula lutea; Macula Lutea - pathology; Male; Measuring instruments; Medicine; Medicine and Health Sciences; Middle Aged; Optical Imaging - instrumentation; Optical Imaging - methods; Patients; Physiological aspects; Research and Analysis Methods; Retina; Sensitivity; Sensitivity analysis; Statistical analysis; Structure-function relationships; Studies; Tomography; University faculty; Visual acuity; Visual field; Visual fields; Japan; Italy
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0151000

This study was conducted in order to compare relationships between the macular visual field (VF) mean sensitivity measured by MAIATM (Macular Integrity Assessment), MP-3, or Humphry field analyzer (HFA) and the ganglion cell and inner plexiform layer (GCA) thicknesses. This cross-sectional study examined 73 glaucoma patients and 19 normal subjects. All subjects underwent measurements for GCA thickness by Cirrus HD-OCT and static threshold perimetry using MAIATM, MP-3, or HFA. VF and OCT in the retinal view were used to examine both the global relationship between the VF sensitivity and GCA thickness, and the superior hemiretina and inferior hemiretina. The relationship between the GCA thickness and macular sensitivity was examined by Spearman correlation analysis. For each instrument, statistically significant macular VF sensitivity (dB) and GCA thickness relationships were observed using the decibel scale (R = 0.547-0.687, all P < 0.001). The highest correlation for the global (R = 0.682) and the superior hemiretina (R = 0.594) GCA thickness-VF mean sensitivity was observed by the HFA. The highest correlation for the inferior hemiretina (R = 0.687) GCA thickness-VF mean sensitivity was observed by the MP-3. Among the three VF measurement instruments, however, no significant differences were found for the structure-function relationships. All three VF measurement instruments found similar structure-function relationships in the central VF.