Dynamic CT perfusion imaging of the myocardium: a technical note on improvement of image quality

To improve image and diagnostic quality in dynamic CT myocardial perfusion imaging (MPI) by using motion compensation and a spatio-temporal filter. Dynamic CT MPI was performed using a 256-slice multidetector computed tomography scanner (MDCT). Data from two different patients-with and without myoca...

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Published inPloS one Vol. 8; no. 10; p. e75263
Main Authors Muenzel, Daniela, Kabus, Sven, Gramer, Bettina, Leber, Vivian, Vembar, Mani, Schmitt, Holger, Wildgruber, Moritz, Fingerle, Alexander A, Rummeny, Ernst J, Huber, Armin, Noël, Peter B
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 09.10.2013
Public Library of Science (PLoS)
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Summary:To improve image and diagnostic quality in dynamic CT myocardial perfusion imaging (MPI) by using motion compensation and a spatio-temporal filter. Dynamic CT MPI was performed using a 256-slice multidetector computed tomography scanner (MDCT). Data from two different patients-with and without myocardial perfusion defects-were evaluated to illustrate potential improvements for MPI (institutional review board approved). Three datasets for each patient were generated: (i) original data (ii) motion compensated data and (iii) motion compensated data with spatio-temporal filtering performed. In addition to the visual assessment of the tomographic slices, noise and contrast-to-noise-ratio (CNR) were measured for all data. Perfusion analysis was performed using time-density curves with regions-of-interest (ROI) placed in normal and hypoperfused myocardium. Precision in definition of normal and hypoperfused areas was determined in corresponding coloured perfusion maps. The use of motion compensation followed by spatio-temporal filtering resulted in better alignment of the cardiac volumes over time leading to a more consistent perfusion quantification and improved detection of the extend of perfusion defects. Additionally image noise was reduced by 78.5%, with CNR improvements by a factor of 4.7. The average effective radiation dose estimate was 7.1±1.1 mSv. The use of motion compensation and spatio-temporal smoothing will result in improved quantification of dynamic CT MPI using a latest generation CT scanner.
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Conceived and designed the experiments: DM SK PBN EJR AH. Performed the experiments: DM BG VL AH PBN. Analyzed the data: DM MW AAF PBN. Contributed reagents/materials/analysis tools: DM SK MV HS PBN. Wrote the paper: DM SK HS MV PBN.
Competing Interests: The authors have declared the following interests: SK and HS are employees of Philips Technologie GmbH; MV is employee of Philips Healthcare. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0075263