The Timing of the Circadian Clock and Sleep Differ between Napping and Non-Napping Toddlers

• Published in: PloS one Vol. 10; no. 4; p. e0125181
• Main Authors: Akacem, Lameese D, Simpkin, Charles T, Carskadon, Mary A, Wright, Jr, Kenneth P, Jenni, Oskar G, Achermann, Peter, LeBourgeois, Monique K
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.04.2015; Public Library of Science (PLoS)
• Subjects: Actigraphy - methods; Child, Preschool; Children; Circadian Clocks; Circadian Rhythm; Circadian rhythms; Female; Females; Humans; Latency; Life span; Male; Melatonin; Melatonin - analysis; Phase relationships; Saliva - chemistry; Schedules; Sleep; Sleep - physiology; Sleep and wakefulness; Time Factors; Toddlers; Variability; Wakefulness
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0125181

The timing of the internal circadian clock shows large inter-individual variability across the lifespan. Although the sleep-wakefulness pattern of most toddlers includes an afternoon nap, the association between napping and circadian phase in early childhood remains unexplored. This study examined differences in circadian phase and sleep between napping and non-napping toddlers. Data were collected on 20 toddlers (34.2±2.0 months; 12 females; 15 nappers). Children followed their habitual napping and non-napping sleep schedules (monitored with actigraphy) for 5 days before an in-home salivary dim light melatonin onset (DLMO) assessment. On average, napping children fell asleep during their nap opportunities on 3.6±1.2 of the 5 days before the DLMO assessment. For these napping children, melatonin onset time was 38 min later (p = 0.044; d = 0.93), actigraphically-estimated bedtime was 43 min later (p = 0.014; d = 1.24), sleep onset time was 59 min later (p = 0.006; d = 1.46), and sleep onset latency was 16 min longer (p = 0.030; d = 1.03) than those not napping. Midsleep and wake time did not differ by napping status. No difference was observed in the bedtime, sleep onset, or midsleep phase relationships with DLMO; however, the wake time phase difference was 47 min smaller for napping toddlers (p = 0.029; d = 1.23). On average, nappers had 69 min shorter nighttime sleep durations (p = 0.006; d = 1.47) and spent 49 min less time in bed (p = 0.019; d = 1.16) than non-nappers. Number of days napping was correlated with melatonin onset time (r = 0.49; p = 0.014). Our findings indicate that napping influences individual variability in melatonin onset time in early childhood. The delayed bedtimes of napping toddlers likely permits light exposure later in the evening, thereby delaying the timing of the clock and sleep. Whether the early developmental trajectory of circadian phase involves an advance associated with the decline in napping is a question necessitating longitudinal data as children transition from a biphasic to monophasic sleep-wakefulness pattern.