Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk

• Published in: PloS one Vol. 8; no. 5; p. e63654
• Main Authors: Xu, Jiali, Yin, Zhiqiang, Cao, Songyu, Gao, Wen, Liu, Lingxiang, Yin, Yongmei, Liu, Ping, Shu, Yongqian
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.05.2013; Public Library of Science (PLoS)
• Subjects: Biology; Cancer; Cancer research; Carcinogenesis; Carcinogens; Cell growth; Cervical cancer; Cervix; Confidence intervals; Cytokines; Development and progression; Disease susceptibility; Epidemiology; Gastric cancer; Genes; Genetic aspects; Genetic Association Studies; Genetic Predisposition to Disease; Health aspects; Health risks; Hepatocellular carcinoma; Humans; Identification methods; Inflammation; Interleukin 1; Interleukin-1beta - genetics; Liver cancer; Lung cancer; Medical ethics; Medicine; Meta-analysis; Models, Genetic; Neoplasms - genetics; Oncology; Polymorphism, Single Nucleotide; Proteins; Publication Bias; Regression Analysis; Risk; Risk Factors; Stomach cancer; Studies; Systematic review; Transcription factors; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0063654

Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, is emerging as a key mediator of carcinogenesis that characterizes host-environment interactions. Epidemiological studies investigating the association between two polymorphisms of IL-1B (-511C/T and +3954C/T) and cancer susceptibility have shown conflicting results. The aim of this study is to derive a more precise estimation of the relationship. Related studies were identified through a systematic literature search of PubMed and Web of Science from their inception to September 15, 2012. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for the IL-1B -511C/T and +3954C/T polymorphisms and cancer risk were calculated. Heterogeneity among studies and publication bias were also tested. The meta-analysis included 91 case-control studies in 85 publications, 81 studies for the -511C/T (19547 cases and 23935 controls) and 26 studies for the +3954C/T polymorphisms (8083 cases and 9183). The pooled results indicated that IL-1B +3954C/T (dominant model: OR = 1.15, 95% CI: 1.01-1.30) was significantly associated with increased overall cancer risk, especially among hospital-based case-control studies (dominant model: OR = 1.30, 95% CI: 1.02-1.66). As for -511C/T, we observed an inverse relationship in cervical cancer (dominant model: OR = 1.74, 95% CI: 1.35-2.23) and hepatocellular carcinoma (dominant model: OR = 0.68, 95% CI: 0.47-0.99). Moreover, -511C/T was associated with risk of specific subtypes of gastric carcinoma. This meta-analysis suggested that both the IL-1B -511C/T and +3954C/T polymorphisms might modulate cancer susceptibility. Further well-designed studies based on larger sample sizes should be performed to confirm the findings.