Small Bowel Stromal Tumors: Different Clinicopathologic and Computed Tomography Features in Various Anatomic Sites

• Published in: PloS one Vol. 10; no. 12; p. e0144277
• Main Authors: Xing, Gu-sheng, Wang, Shuang, Sun, Yue-Min, Yuan, Zheng, Zhao, Xin-Ming, Zhou, Chun-wu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.12.2015; Public Library of Science (PLoS)
• Subjects: Adult; Analysis; Cancer; Care and treatment; CAT scans; Committees; Complications and side effects; Computation; Computed tomography; Diagnosis; Duodenum; Female; Gastroenterology; Gastrointestinal cancer; Gene expression; Heterogeneity; Hospitals; Humans; Ileum; Image enhancement; Intestinal Neoplasms - diagnostic imaging; Intestinal Neoplasms - pathology; Intestine, Small - diagnostic imaging; Intestine, Small - pathology; Jejunum; Lymphadenopathy; Male; Medical diagnosis; Medical imaging; Medical prognosis; Metastases; Middle Aged; Oncology; Pathology; Patients; Radiology; Risk; Small intestine; Stomach cancer; Surgery; Survival analysis; Tomography; Tomography, X-Ray Computed; Tumors
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0144277

Gastrointestinal stromal tumors (GISTs) can present with different clinical and immunohistochemical characteristics according to different anatomic sites. The aim of this study was to compare clinicopathologic and computed tomography (CT) features of small bowel stromal tumors located in the duodenum, jejunum, and ileum. In total, 197 patients (109 male, 88 female) with small bowel GISTs were retrospectively reviewed. All tumors had definite anatomic sites in the small bowel tract with surgical confirmation. The clinicopathologic variables included age, sex, onset of symptoms, and tumor risk category. CT variables included tumor size, degree enhancement, enhancement pattern (region of necrosis), adjacent tissue involvement, lymphadenopathy, and distant metastasis. We assessed any possible differences according to different GIST site of origin. Based on tumor size and mitotic count, the risk categories in different anatomic sites did not differ significantly between duodenal and jejunal GISTs. However, high risk ileum GISTs accounted for 66.0% of ileal cases, which was higher than duodenum cases (36.8%, P = 0.002) and jejunum cases (43.9%, P = 0.004). The mean size of GISTs in the ileum was 9.77 cm, which was significantly larger than in the duodenum (7.41 cm, P = 0.043), and in the jejunum (8.14 cm, P = 0.027). On CT images, enhancement degree appeared to gradually increase from the duodenum to the ileum in the portal phase, and the enhancement pattern presented a tendency for heterogeneity. In Conclusions, the clinicopathologic and CT features of small bowel GISTs can differ according to different primary anatomic sites.