Neural activity in the prelimbic and infralimbic cortices of freely moving rats during social interaction: Effect of isolation rearing

• Published in: PloS one Vol. 12; no. 5; p. e0176740
• Main Authors: Minami, Chihiro, Shimizu, Tomoko, Mitani, Akira
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2017; Public Library of Science (PLoS)
• Subjects: Action Potentials; Animal behavior; Animals; Biology and Life Sciences; Brain; Brain research; Cerebral Cortex - physiopathology; Choice Behavior - physiology; Disorders; Electrodes, Implanted; Exploratory Behavior - physiology; Firing; Group dynamics; Housing, Animal; Male; Medical examination; Medicine and Health Sciences; Mental disorders; Motor Activity - physiology; Neural circuitry; Neurology; Neurons; Neurons - physiology; Prefrontal cortex; Psychological aspects; Rats; Rats, Sprague-Dawley; Research and Analysis Methods; Rodents; Social Behavior; Social isolation; Social Isolation - psychology; Socialization; Telemetry; Time Factors; Wireless Technology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0176740

Sociability promotes a sound daily life for individuals. Reduced sociability is a central symptom of various neuropsychiatric disorders, and yet the neural mechanisms underlying reduced sociability remain unclear. The prelimbic cortex (PL) and infralimbic cortex (IL) have been suggested to play an important role in the neural mechanisms underlying sociability because isolation rearing in rats results in impairment of social behavior and structural changes in the PL and IL. One possible mechanism underlying reduced sociability involves dysfunction of the PL and IL. We made a wireless telemetry system to record multiunit activity in the PL and IL of pairs of freely moving rats during social interaction and examined the influence of isolation rearing on this activity. In group-reared rats, PL neurons increased firing when the rat showed approaching behavior and also contact behavior, especially when the rat attacked the partner. Conversely, IL neurons increased firing when the rat exhibited leaving behavior, especially when the partner left on its own accord. In social interaction, the PL may be involved in active actions toward others, whereas the IL may be involved in passive relief from cautionary subjects. Isolation rearing altered social behavior and neural activity. Isolation-reared rats showed an increased frequency and decreased duration of contact behavior. The increased firing of PL neurons during approaching and contact behavior, observed in group-reared rats, was preserved in isolation-reared rats, whereas the increased firing of IL neurons during leaving behavior, observed in group-reared rats, was suppressed in isolation-reared rats. This result indicates that isolation rearing differentially alters neural activity in the PL and IL during social behavior. The differential influence of isolation rearing on neural activity in the PL and IL may be one of the neural bases of isolation rearing-induced behavior.