Surgical outcomes of pulmonary mucoepidermoid carcinoma: A review of 41 cases

• Published in: PloS one Vol. 12; no. 5; p. e0176918
• Main Authors: Hsieh, Chih-Cheng, Sun, Yung-Han, Lin, Shih-Wei, Yeh, Yi-Chen, Chan, Mei-Lin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.05.2017; Public Library of Science (PLoS)
• Subjects: Adenocarcinoma; Adenoid; Adenosquamous; Adolescent; Adult; Adults; Age; Age Factors; Aged; Aged, 80 and over; Arches; Autopsies; Autopsy; Biochemistry; Biology and Life Sciences; Biopsy; Bronchoscopy; Cancer; Carcinoma, Mucoepidermoid - pathology; Carcinoma, Mucoepidermoid - surgery; Care and treatment; Cell survival; Chin; Chromosome 11; Clinical medicine; Committees; Computation; Computed tomography; Computer programs; Diagnosis; Engineering; Epidemiology; Epithelium; Evaluation; Female; Follow-Up Studies; Glands; Head and neck; Heart; Histology; Hospitals; Humans; Incidence; Jaw; Lung cancer; Lung diseases; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Lungs; Male; Mathematical models; Medical diagnosis; Medical prognosis; Medicine; Medicine and Health Sciences; Metastases; Metastasis; Middle Aged; Multivariate Analysis; Neoplasm Grading; Neoplasm Recurrence, Local; Neurology; Older people; Pathology; Patient outcomes; Patients; People and Places; Physical Sciences; Positron emission tomography; Prognosis; Prospective Studies; Quality; Regression analysis; Research and Analysis Methods; Retrospective Studies; Social sciences; Stroke; Surgery; Surgical outcomes; Survival; Survival Analysis; Thoracic surgery; Thorax; Thymus; Tumor Burden; Tumors; Young Adult; United States; United States > US; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0176918

Pulmonary mucoepidermoid carcinoma is a rare cancer that occurs primarily in younger patients. The prognostic factors of pulmonary mucoepidermoid carcinoma are largely undetermined, especially in elderly patients. The aim of this study was to examine the clinical characteristics and prognostic factors influencing survival after surgical resection in patients with pulmonary mucoepidermoid carcinoma and also analyze the clinical manifestations and prognostic factors in elderly patients. The pathological records of 41 pulmonary mucoepidermoid carcinoma patients (mean age, 61.4 years) who underwent surgical resection at our hospital between January 1991 and July 2015 were retrospectively reviewed. Subjects >65 years of age (n = 22) were considered elderly. The median follow-up duration was 42.9 (interquartile range, 15.0-120.8) months. Sixteen patients (39.0%) experienced tumor relapse, including 13 patients (81.3%) within 2 years. The 5-year disease-free survival rate was 57.9%. Tumor grade did not influence disease-free survival (P = 0.286). In the multivariate analysis, age, tumor size, pathological T3-4 status, and pathological N2 status were independent predictors of disease-free survival. The 5-year overall survival rate was 57.0%. Tumor grade also did not influence overall survival (P = 0.170). Age, tumor size, pathological T status, and pathological N2 status were independent predictors of overall survival. In elderly patients, the 5-year disease-free survival and overall survival rates were 41.4% and 41.5%, respectively. Pathological T status was the only independent predictor of both disease-free survival and overall survival in elderly patients. Prognostic factors identified for pulmonary mucoepidermoid carcinoma in this study differ from those of previous studies. Principally, tumor grade did not influence either disease-free survival or overall survival. Age, tumor size, and pathological factors were independent predictors of disease-free survival and overall survival. In elderly patients, pathological T status was the only independent predictor of disease-free survival and overall survival.