Functional neural correlates of attentional deficits in amnestic mild cognitive impairment
Although amnestic mild cognitive impairment (aMCI; often considered a prodromal phase of Alzheimer's disease, AD) is most recognized by its implications for decline in memory function, research suggests that deficits in attention are present early in aMCI and may be predictive of progression to...
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Published in | PloS one Vol. 8; no. 1; p. e54035 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
11.01.2013
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
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Summary: | Although amnestic mild cognitive impairment (aMCI; often considered a prodromal phase of Alzheimer's disease, AD) is most recognized by its implications for decline in memory function, research suggests that deficits in attention are present early in aMCI and may be predictive of progression to AD. The present study used functional magnetic resonance imaging to examine differences in the brain during the attention network test between 8 individuals with aMCI and 8 neurologically healthy, demographically matched controls. While there were no significant behavioral differences between groups for the alerting and orienting functions, patients with aMCI showed more activity in neural regions typically associated with the networks subserving these functions (e.g., temporoparietal junction and posterior parietal regions, respectively). More importantly, there were both behavioral (i.e., greater conflict effect) and corresponding neural deficits in executive control (e.g., less activation in the prefrontal and anterior cingulate cortices). Although based on a small number of patients, our findings suggest that deficits of attention, especially the executive control of attention, may significantly contribute to the behavioral and cognitive deficits of aMCI. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: MS PRH JF. Performed the experiments: MS EMM HTG XG YP JF. Analyzed the data: NTVD JF. Contributed reagents/materials/analysis tools: NTVD JF. Wrote the paper: NTVD MS EMM HTG XG YP PRH JF. Competing Interests: Nicholas T. Van Dam, Effie M. Mitsis, Xiaosi Gu, Yunsoo Park, Hillel T. Grossman, Patrick R. Hof, & Jin Fan have no current competing interests to declare. Mary Sano acts as a consultant for Vital Images, Inc. and serves on the Scientific Advisory Board of Medivation, Inc. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. |
ISSN: | 1932-6203 1932-6203 |
DOI: | 10.1371/journal.pone.0054035 |