Quantitative Evaluation of Human Cerebellum-Dependent Motor Learning through Prism Adaptation of Hand-Reaching Movement

• Published in: PloS one Vol. 10; no. 3; p. e0119376
• Main Authors: Hashimoto, Yuji, Honda, Takeru, Matsumura, Ken, Nakao, Makoto, Soga, Kazumasa, Katano, Kazuhiko, Yokota, Takanori, Mizusawa, Hidehiro, Nagao, Soichi, Ishikawa, Kinya
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.03.2015; Public Library of Science (PLoS)
• Subjects: Adaptability; Adaptation; Adult; Age; Aged; Aging; Aging - physiology; Analysis; Ataxia; Brain; Case-Control Studies; Cerebellar Ataxia - physiopathology; Cerebellum; Cerebellum - physiopathology; Clinical trials; Disease; Disease Progression; Female; Fingers - physiology; Goggles; Human motion; Humans; Interactive computer systems; Laboratories; Learning; Male; Middle Aged; Motor Activity - physiology; Motor skill learning; Neurology; Paradigms; Patients; Pattern Recognition, Physiological - physiology; Pattern Recognition, Visual - physiology; Psychomotor Performance - physiology; Quantitative analysis; Science; Studies; Study and teaching; Touch screens; Trends; Visual field; Visual fields; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0119376

The cerebellum plays important roles in motor coordination and learning. However, motor learning has not been quantitatively evaluated clinically. It thus remains unclear how motor learning is influenced by cerebellar diseases or aging, and is related with incoordination. Here, we present a new application for testing human cerebellum-dependent motor learning using prism adaptation. In our paradigm, the participant wearing prism-equipped goggles touches their index finger to the target presented on a touchscreen in every trial. The whole test consisted of three consecutive sessions: (1) 50 trials with normal vision (BASELINE), (2) 100 trials wearing the prism that shifts the visual field 25° rightward (PRISM), and (3) 50 trials without the prism (REMOVAL). In healthy subjects, the prism-induced finger-touch error, i.e., the distance between touch and target positions, was decreased gradually by motor learning through repetition of trials. We found that such motor learning could be quantified using the "adaptability index (AI)", which was calculated by multiplying each probability of [acquisition in the last 10 trials of PRISM], [retention in the initial five trials of REMOVAL], and [extinction in the last 10 trials of REMOVAL]. The AI of cerebellar patients less than 70 years old (mean, 0.227; n = 62) was lower than that of age-matched healthy subjects (0.867, n = 21; p < 0.0001). While AI did not correlate with the magnitude of dysmetria in ataxic patients, it declined in parallel with disease progression, suggesting a close correlation between the impaired cerebellar motor leaning and the dysmetria. Furthermore, AI decreased with aging in the healthy subjects over 70 years old compared with that in the healthy subjects less than 70 years old. We suggest that our paradigm of prism adaptation may allow us to quantitatively assess cerebellar motor learning in both normal and diseased conditions.