Sarcopenia is an effective predictor of difficult-to-wean and mortality among critically ill surgical patients

• Published in: PloS one Vol. 14; no. 8; p. e0220699
• Main Authors: Kou, Hao-Wei, Yeh, Chih-Hua, Tsai, Hsin-I, Hsu, Chih-Chieh, Hsieh, Yi-Chung, Chen, Wei-Ting, Cheng, Hao-Tsai, Yu, Ming-Chin, Lee, Chao-Wei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.08.2019; Public Library of Science (PLoS)
• Subjects: Aged; Aged, 80 and over; Analysis; Biology and Life Sciences; CAT scans; Computed tomography; Critical Illness - mortality; Critical Illness - therapy; Critically ill persons; Decision making; Demographics; Female; Health aspects; Hospital Mortality; Hospital patients; Hospitals; Humans; Intensive care; Intensive Care Units; Male; Mechanical ventilation; Medical research; Medicine; Medicine and Health Sciences; Middle Aged; Mortality; Muscle strength; Musculoskeletal system; Parameters; Pneumonia; Postoperative Period; Predictive Value of Tests; Psoas muscle; Psoas Muscles - diagnostic imaging; Regression analysis; Research and Analysis Methods; Respiration; Risk analysis; Risk Factors; ROC Curve; Sarcopenia; Sarcopenia - diagnosis; Sarcopenia - mortality; Sepsis; Surgery; Surgical outcomes; Taiwan; Tomography; Tomography, X-Ray Computed; Ventilation; Ventilator Weaning; Ventilators; Vertebrae; Weaning; Taiwan; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0220699

Critically-ill surgical patients are at higher risk for sarcopenia, which is associated with worse survival. Sarcopenia may impair the respiratory musculature, which can subsequently influence the outcome of ventilator weaning. Although there are a variety of weaning parameters predictive of weaning outcomes, none have tried to incorporate "muscle strength" or "sarcopenia". The aim of the current study was to explore the association between sarcopenia and difficult-to-wean (DtW) in critically-ill surgical patients. The influence of sarcopenia on ICU mortality was also analyzed. Ninety-six patients undergoing mechanical ventilation in the surgical intensive care unit (ICU) were enrolled. Demographic data and weaning parameters were recorded from the prospectively collected database, and the total psoas muscle area (TPA) was determined at the level of the 3rd lumbar vertebra by computed tomography. Sarcopenia was defined by previously established cut-off points and its influence on clinical outcomes was examined. Receiver operating characteristic (ROC) curve analysis was conducted to investigate the predictive capability of TPA and weaning parameters for predicting weaning outcomes. The median age of the studied patients was 73 years. Thirty patients (31.3%) were sarcopenic and 30 (31.3%) were defined as DtW. Eighteen patients (18.8%) had ICU mortality. Multivariate logistic regression analyses revealed that sarcopenia was an independent risk factor for DtW and ICU mortality. The area under the ROC curve (AUC) of TPA for predicting successful weaning was 0.727 and 0.720 in female and male patients, respectively. After combining TPA and conventional weaning parameters, the AUC for DtW increased from 0.836 to 0.911 and from 0.835 to 0.922 in female and male patients, respectively. Sarcopenia is an independent risk factor for DtW and ICU mortality. TPA has predictive value when assessing weaning outcomes and can be used as an effective adjunct predictor along with conventional weaning parameters.