Effective new membrane for preventing postthoracotomy pleural adhesion by surface water induction technology

After thoracic surgery, adhesions between the pleura can cause substantial complications. This study investigated the effectiveness of a novel membrane utilizing surface water induction technology to prevent adhesions. Eight beagles were divided into an experimental group (five males) and a control...

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Bibliographic Details
Published inPloS one Vol. 12; no. 6; p. e0179815
Main Authors Uemura, Akiko, Nakata, Mary, Goya, Seijirow, Fukayama, Toshiharu, Tanaka, Ryou
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 27.06.2017
Public Library of Science (PLoS)
Subjects
Abdomen
Absorbable Implants
Adhesion
Adhesion tests
Adhesives
Animals
Biology and Life Sciences
Cell adhesion
Complications
Dogs
Earth Sciences
Female
Females
Health aspects
Laboratory animals
Male
Males
Medicine and Health Sciences
Ostomy
Patient outcomes
Pharmaceuticals
Pleura
Pleural Diseases - etiology
Pleural Diseases - prevention & control
Postoperative Complications - etiology
Postoperative Complications - prevention & control
Prevention
Skin care products
Sodium
Studies
Surface water
Surgery
Technology
Thoracic surgery
Thoracotomy
Thoracotomy - adverse effects
Thorax
Tissue Adhesions - etiology
Tissue Adhesions - prevention & control
Japan
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Summary:After thoracic surgery, adhesions between the pleura can cause substantial complications. This study investigated the effectiveness of a novel membrane utilizing surface water induction technology to prevent adhesions. Eight beagles were divided into an experimental group (five males) and a control group (three females). The experimental group underwent thoracotomy on both the left and right sides of the chest. Both sides received the membrane, and the membrane on one side was glued to the pleura using tissue adhesive. The control group underwent thoracotomy only on the left side. Two weeks postoperatively, all dogs were sacrificed and adhesions were evaluated macroscopically and microscopically. Severe adhesion was seen between the parietal and visceral pleura in all control dogs, whereas the experimental group showed minor adhesion in only one dog on one side. Our novel anti-adhesive membrane appeared highly effective in preventing postthoracotomy pleural adhesions.
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Competing Interests: This study was carried out as a collaborative development project contracted by the Japan Science and Technology Agency as recommissioned research for a membrane utilizing surface water induction technology to prevent pleural adhesions. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Conceptualization: AU RT.Data curation: AU MN SG TF RT.Formal analysis: AU FT RT.Funding acquisition: RT.Investigation: AU MN SG TF RT.Methodology: AU RT.Project administration: AU RT.Software: AU RT.Supervision: AU RT.Validation: AU FT RT.Writing – original draft: AU.Writing – review & editing: AU.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0179815