Acquired Cystic Disease-Associated Renal Cell Carcinoma: Review of Pathogenesis, Morphology, Ancillary Tests, and Clinical Features

Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a recently described subtype of RCC found in individuals with ACD of the kidney. Because of underrecognition, information regarding this lesion is sparse but continues to accumulate with each new report. Herein, a thorough literatu...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 141; no. 4; pp. 600 - 606
Main Authors Foshat, Michelle, Eyzaguirre, Eduardo
Format Journal Article
LanguageEnglish
Published United States College of American Pathologists 01.04.2017
Subjects
Biomarkers, Tumor - metabolism
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - therapy
Care and treatment
Causes of
Chromosome Aberrations
Development and progression
Diagnosis
Diagnosis, Differential
Humans
Kidney - metabolism
Kidney - pathology
Kidney diseases
Kidney Diseases, Cystic - metabolism
Kidney Diseases, Cystic - pathology
Kidney Diseases, Cystic - therapy
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidney Neoplasms - therapy
Morphology (Biology)
Patient outcomes
Prognosis
Renal cell carcinoma
Treatment Outcome
United States
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Summary:Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a recently described subtype of RCC found in individuals with ACD of the kidney. Because of underrecognition, information regarding this lesion is sparse but continues to accumulate with each new report. Herein, a thorough literature review amassing the current understanding of this unique neoplasm is presented. Discussion focuses on clinical features, pathogenesis, disease outcome, and relation to the duration of dialysis. The macroscopic and characteristic microscopic features are described with illustrations. Compared with previous opinion, compiled immunohistochemical data may now allow for recognition of a unique immunophenotypic pattern of ACD-RCC. Distinction of ACD-RCC from clear cell and papillary RCCs based on molecular genetic information is deliberated, including a summary of the most frequently detected cytogenetic abnormalities. The key morphologic and immunophenotypic patterns used to distinguish this entity from a comprehensive differential diagnosis are provided.
Bibliography:ObjectType-Article-2
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ISSN:0003-9985
1543-2165
1543-2165
DOI:10.5858/arpa.2016-0123-rs