Central Crosstalk for Somatic Tinnitus: Abnormal Vergence Eye Movements

• Published in: PloS one Vol. 5; no. 7; p. e11845
• Main Authors: Yang, Qing, Vernet, Marine, Orssaud, Christophe, Bonfils, Pierre, Londero, Alain, Kapoula, Zoi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.07.2010; Public Library of Science (PLoS)
• Subjects: Adaptation; Adult; Adults; Analysis of Variance; Auditory pathways; Auditory signals; Brain stem; Cerebellum; Cognitive science; Convergence, Ocular - physiology; Cortex; Crosstalk; Divergence; Eye; Eye movements; Female; Hearing loss; Humans; Jaw; Latency; Male; Medical research; Metabolism; Middle Aged; Neck; Neuroscience; Neuroscience/Behavioral Neuroscience; Neuroscience/Sensory Systems; Otolaryngology/Audiology; Patients; Physiology; Saccades (Eye movements); Skin; Tinnitus; Tinnitus - physiopathology; Traumatic brain injury; Velocity; Vergence eye movements; Young Adult; France
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0011845

Frequent oulomotricity problems with orthoptic testing were reported in patients with tinnitus. This study examines with objective recordings vergence eye movements in patients with somatic tinnitus patients with ability to modify their subjective tinnitus percept by various movements, such as jaw, neck, eye movements or skin pressure. Vergence eye movements were recorded with the Eyelink II video system in 15 (23-63 years) control adults and 19 (36-62 years) subjects with somatic tinnitus. 1) Accuracy of divergence but not of convergence was lower in subjects with somatic tinnitus than in control subjects. 2) Vergence duration was longer and peak velocity was lower in subjects with somatic tinnitus than in control subjects. 3) The number of embedded saccades and the amplitude of saccades coinciding with the peak velocity of vergence were higher for tinnitus subjects. Yet, saccades did not increase peak velocity of vergence for tinnitus subjects, but they did so for controls. 4) In contrast, there was no significant difference of vergence latency between these two groups. The results suggest dysfunction of vergence areas involving cortical-brainstem-cerebellar circuits. We hypothesize that central auditory dysfunction related to tinnitus percept could trigger mild cerebellar-brainstem dysfunction or that tinnitus and vergence dysfunction could both be manifestations of mild cortical-brainstem-cerebellar syndrome reflecting abnormal cross-modality interactions between vergence eye movements and auditory signals.