Multiphoton Ionization Time-of-Flight Mass Spectrometry for the Detection of Bioactive Lignan

• Published in: Analytical Sciences Vol. 32; no. 2; pp. 255 - 257
• Main Authors: UCHIMURA, Tomohiro, TOKUMOTO, Goro, BATNYAM, Onon, CHOU, Chih-Wei, FUJITA, Satoshi
• Format: Journal Article
• Language: English
• Published: Singapore The Japan Society for Analytical Chemistry 2016; Springer Nature Singapore; Japan Science and Technology Agency
• Subjects: Analytical Chemistry; anticancer drug; Antineoplastic Agents - chemistry; Chemistry; Furans - analysis; Furans - chemistry; Hot Temperature; Inlet nozzles; Ionization; Lasers; Ligands; lignan; Lignans; Lignans - analysis; Lignans - chemistry; Liquids; Mass spectrometry; MPI-TOFMS; Photons; Pulsed lasers; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Taiwanin A; Vaporization; Volatility; Volatilization; lignan; anticancer drug; MPI-TOFMS; Taiwanin A
• ISSN: 0910-6340; 1348-2246
• DOI: 10.2116/analsci.32.255

Multiphoton ionization time-of-flight mass spectrometry (MPI-TOFMS) combined with a pulsed laser for sample vaporization was developed for the detection of a low-volatile compound in a solution. A solution containing Taiwanin A ((3E,4E)-3,4-bis(1,3-benzodioxol-5-ylmethylene)dihydro-2(3H)-furanone), which is a lignan that has an anticancer effect, was employed in the present study. Consequently, Taiwanin A could be detected by irradiating a laser pulse for vaporization to an inlet nozzle, rather than by heating. Therefore, the present method could be effective for detecting compounds with lower volatilities in a liquid sample.