Paramount Definition of Reference Interval for Biochemistry Parameters in Indian Sub-Population: A Healthy Adult Population Based Cross Sectional Study

• Published in: RGUHS Journal of Allied Health Sciences Vol. 2; no. 2
• Main Authors: Babu SV, Suresh, S, Narayana, HR, Suma, Shenoy R, Rajesh
• Format: Journal Article
• Language: English
• Published: 2022
• ISSN: 2583-3782; 2583-3782
• DOI: 10.26463/rjahs.2_2_6

Background Biological reference intervals BRI of most of the laboratory parameters are significantly influenced by lifestyle and need to be reviewed periodically.Objectives To determine the reference intervals of common clinical-chemistry parameters such as fasting glucose urea creatinine total cholesterol triglycerides HDL- C Direct LDL-C Direct VLDL-C uric acid total protein albumin T. Bilirubin D. Bilirubin ALT AST g - GT ALP for the healthy adult population and to validate the newly established BRI for national applicability. Methodology A cross sectional observational study was conducted including 253 subjects with a mean age of 38.5plusmn8.7 years belonging to four geographical regions such as Kerala Karnataka Andhra Pradesh and Tamil Nadu. The analytes were measured using standard methods.Results Some of the reference intervals of common clinical chemistry parameters in healthy adults of Indian sub-population were lower than the real-world reference intervals however they were within the range. The important parameters such as blood urea creatinine uric acid total cholesterol total bilirubin and g- GT values were significantly lower than the mean reference interval by 35 30 16 9 20 and 57 respectively. However they were within the range while LDL- Cholesterol level was 37 above the mean reference limit. Rest of the parameters were harmonized with the reference interval.Conclusion The BRI were established in this study by constituting apparently healthy South Indian population. It may be a stepping platform and practical role in the determination of BRI of clinical-chemistry analytes in the future for Pan India.nbsp