Cerebral Syphilitic Gumma in Immunocompetent Man, Japan
Although cerebral syphilitic gummas are generally considered to be rare manifestations of tertiary syphilis, many reports exist of early cerebral syphilitic gumma. Our finding of cerebral syphilitic gumma in an HIV-negative man within 5 months after syphilis infection suggests that this condition sh...
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| Published in | Emerging Infectious Diseases Vol. 24; no. 2; pp. 395 - 396 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Centers for Disease Control and Prevention (CDC)
01.02.2018
U.S. National Center for Infectious Diseases Centers for Disease Control and Prevention |
| Subjects | |
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| Abstract | Although cerebral syphilitic gummas are generally considered to be rare manifestations of tertiary syphilis, many reports exist of early cerebral syphilitic gumma. Our finding of cerebral syphilitic gumma in an HIV-negative man within 5 months after syphilis infection suggests that this condition should be considered in syphilis patients who have neurologic symptoms. |
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| AbstractList | Although cerebral syphilitic gummas are generally considered to be rare manifestations of tertiary syphilis, many reports exist of early cerebral syphilitic gumma. Our finding of cerebral syphilitic gumma in an HIV-negative man within 5 months after syphilis infection suggests that this condition should be considered in syphilis patients who have neurologic symptoms.Although cerebral syphilitic gummas are generally considered to be rare manifestations of tertiary syphilis, many reports exist of early cerebral syphilitic gumma. Our finding of cerebral syphilitic gumma in an HIV-negative man within 5 months after syphilis infection suggests that this condition should be considered in syphilis patients who have neurologic symptoms. Although cerebral syphilitic gummas are generally considered to be rare manifestations of tertiary syphilis, many reports exist of early cerebral syphilitic gumma. Our finding of cerebral syphilitic gumma in an HIV-negative man within 5 months after syphilis infection suggests that this condition should be considered in syphilis patients who have neurologic symptoms. |
| Audience | Professional Academic |
| Author | Yuji Fujikura Akihiko Kawana Hidenori Sato Tatsuya Kodama Morichika Osa |
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| BackLink | https://cir.nii.ac.jp/crid/1870020693001787520$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/29350164$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/OLQ.0000000000000701 10.1212/WNL.42.7.1282 10.3201/eid2210.160600 10.1056/NEJMra1301635 10.1111/jdv.12734 10.1227/01.NEU.0000337079.12137.89 10.1177/0956462415624059 10.1056/NEJM199412013312204 |
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| Keywords | syphilitic gumma bacteria sexually transmitted infections Japan syphilis neurosyphilis cerebral syphilitic gumma |
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| References | Zhang (key-10.3201/eid2402.171444-201801171307-R5) 2016; 18 Berger (key-10.3201/eid2402.171444-201801171307-R3) 1992; 42 Fargen (key-10.3201/eid2402.171444-201801171307-R6) 2009; 64 Koizumi (key-10.3201/eid2402.171444-201801171307-R10) 2017 Brouwer (key-10.3201/eid2402.171444-201801171307-R1) 2014; 371 Tsuboi (key-10.3201/eid2402.171444-201801171307-R9) 2016; 22 Kingston (key-10.3201/eid2402.171444-201801171307-R2) 2016; 27 Berger (key-10.3201/eid2402.171444-201801171307-R7) 1992; 42 Horowitz (key-10.3201/eid2402.171444-201801171307-R4) 1994; 331 Janier (key-10.3201/eid2402.171444-201801171307-R8) 2014; 28 |
| References_xml | – start-page: 1 year: 2017 ident: key-10.3201/eid2402.171444-201801171307-R10 article-title: Cerebral syphilitic gumma can arise within months of reinfection: a case of histologically proven treponema pallidum strain type 14b/f infection with human immunodeficiency virus positivity. publication-title: Sex Transm Dis doi: 10.1097/OLQ.0000000000000701 – volume: 42 start-page: 1282 year: 1992 ident: key-10.3201/eid2402.171444-201801171307-R3 article-title: Syphilitic cerebral gumma with HIV infection. publication-title: Neurology doi: 10.1212/WNL.42.7.1282 – volume: 22 start-page: 1846 year: 2016 ident: key-10.3201/eid2402.171444-201801171307-R9 article-title: Cerebral syphilitic gumma within 5 months of syphilis in HIV-infected patient. publication-title: Emerg Infect Dis doi: 10.3201/eid2210.160600 – volume: 371 start-page: 447 year: 2014 ident: key-10.3201/eid2402.171444-201801171307-R1 article-title: Brain abscess. publication-title: N Engl J Med doi: 10.1056/NEJMra1301635 – volume: 28 start-page: 1581 year: 2014 ident: key-10.3201/eid2402.171444-201801171307-R8 article-title: 2014 European guideline on the management of syphilis. publication-title: J Eur Acad Dermatol Venereol doi: 10.1111/jdv.12734 – volume: 42 start-page: 1282 year: 1992 ident: key-10.3201/eid2402.171444-201801171307-R7 article-title: Syphilitic cerebral gumma with HIV infection. publication-title: Neurology doi: 10.1212/WNL.42.7.1282 – volume: 18 start-page: 1 year: 2016 ident: key-10.3201/eid2402.171444-201801171307-R5 article-title: A case of cerebral syphilitic gumma developed in a few months mimicking a brain tumor in a human immunodeficiency virus–negative patient. publication-title: Br J Neurosurg – volume: 64 year: 2009 ident: key-10.3201/eid2402.171444-201801171307-R6 article-title: Cerebral syphilitic gummata: a case presentation and analysis of 156 reported cases publication-title: Neurosurgery doi: 10.1227/01.NEU.0000337079.12137.89 – volume: 27 start-page: 421 year: 2016 ident: key-10.3201/eid2402.171444-201801171307-R2 article-title: UK national guidelines on the management of syphilis 2015. publication-title: Int J STD AIDS doi: 10.1177/0956462415624059 – volume: 331 start-page: 1488 year: 1994 ident: key-10.3201/eid2402.171444-201801171307-R4 article-title: Brief report: cerebral syphilitic gumma confirmed by the polymerase chain reaction in a man with human immunodeficiency virus infection. publication-title: N Engl J Med doi: 10.1056/NEJM199412013312204 |
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| SubjectTerms | Adult Anti-Bacterial Agents - therapeutic use bacteria Ceftriaxone - therapeutic use Cerebral Syphilitic Gumma in Immunocompetent Man, Japan Health aspects Humans Immunocompromised Host Infectious and parasitic diseases Japan Japan - epidemiology Male Medical schools Medicine neurosyphilis Neurosyphilis - diagnosis Neurosyphilis - diagnostic imaging Neurosyphilis - drug therapy Neurosyphilis - epidemiology R RC109-216 Research Letter Sex oriented businesses sexually transmitted infections Syphilis syphilitic gumma |
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| Title | Cerebral Syphilitic Gumma in Immunocompetent Man, Japan |
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