Whole-Genome Sequencing of Shiga Toxin–Producing Escherichia coli OX18 from a Fatal Hemolytic Uremic Syndrome Case

• Published in: Emerging infectious diseases Vol. 27; no. 5; pp. 1509 - 1512
• Main Authors: Lee, Kenichi, Iguchi, Atsushi, Uda, Kazuhiro, Matsumura, Sohshi, Miyairi, Isao, Ishikura, Kenji, Ohnishi, Makoto, Seto, Junji, Ishikawa, Kanako, Konishi, Noriko, Obata, Hiromi, Furukawa, Ichiro, Nagaoka, Hiromi, Morinushi, Hirotaka, Hama, Natsuki, Nomoto, Ryohei, Nakajima, Hiroshi, Kariya, Hideaki, Hamasaki, Mitsuhiro, Iyoda, Sunao
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.05.2021; Centers for Disease Control and Prevention
• Subjects: Antigens; Archives & records; Asymptomatic; Bacteria; Case studies; Cattle; Causes of; Complications and side effects; Diagnosis; Dispatch; DNA sequencing; E coli; Environmental science; Epidemics; Escherichia coli infections; foodborne pathogens; Genes; Genomes; Genomics; Health surveillance; Hemolytic-uremic syndrome; Infectious diseases; Nucleotide sequencing; Og-typing; Original Research; OX18; Pathogenesis; Pediatric research; Phylogenetics; Plasmids; Public health; R&D; Research & development; Shiga toxin–producing Escherichia coli; Toxins; Urinary tract diseases; Urinary tract infections; Urogenital system; Virulence; Whole genome sequencing; Whole-Genome Sequencing of Shiga Toxin–Producing; Japan; food safety; Og-typing; foodborne pathogens; OX18; Shiga toxin–producing Escherichia coli; Japan; whole-genome sequencing; Bacteria; STEC; enteric infections; E. coli
• ISSN: 1080-6040; 1080-6059; 1080-6059
• DOI: 10.3201/eid2705.204162

We report a fatal case of hemolytic uremic syndrome with urinary tract infection in Japan caused by Shiga toxin-producing Escherichia coli. We genotypically identified the isolate as OX18:H2. Whole-genome sequencing revealed 3 potentially pathogenic lineages (OX18:H2, H19, and H34) that have been continuously isolated in Japan.