Polymorphisms of caprine PrP gene detected in Japan

Polymorphism of the PrP gene is a primary factor influencing susceptibility and incubation period in natural and experimental scrapie in sheep and goats. Polymorphisms of the caprine PrP gene in Japan were examined in 118 goats. Eight allelic variants and 19 genotypes were obtained. Amino scid polym...

Full description

Saved in:
Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 67; no. 3; pp. 321 - 323
Main Authors Kurosaki, Y. (Obihiro Univ. of Agriculture and Veterinary Medicine, Hokkaido (Japan)), Ishiguro, N, Horiuchi, M, Shinagawa, M
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.03.2005
Japan Science and Technology Agency
Subjects
Alleles
Amino Acid Sequence
Animals
Genotype
Geography
goat
GOATS
Goats - genetics
JAPAN
Molecular Sequence Data
POLYMORPHISM
Polymorphism, Genetic
PRIONS
Prions - genetics
PrP
SCRAPIE
Sequence Analysis, DNA - veterinary
Japan
Online AccessGet full text

Cover

More Information
Summary:Polymorphism of the PrP gene is a primary factor influencing susceptibility and incubation period in natural and experimental scrapie in sheep and goats. Polymorphisms of the caprine PrP gene in Japan were examined in 118 goats. Eight allelic variants and 19 genotypes were obtained. Amino scid polymorphisms were observed at 7 codons: 102, 142, 143, 240, 127, l46 and 211 (the latter 3 are novel polymorphisms). The polymorphisms at codorn I42M and l43R. which are associated with the resistance to scrapie, were relatively rare in the present study. Thus, the present results provide information about the caprine PrP gene that may be useful for assessing the risk of goat scrapie.
Bibliography:L70
2005005415
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.67.321