Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study

• Published in: The Lancet (British edition) Vol. 377; no. 9781; pp. 1938 - 1947
• Main Authors: Harkema, Susan, Prof, Gerasimenko, Yury, PhD, Hodes, Jonathan, MD, Burdick, Joel, Prof, Angeli, Claudia, PhD, Chen, Yangsheng, PhD, Ferreira, Christie, BSc, Willhite, Andrea, BA, Rejc, Enrico, MSc, Grossman, Robert G, Prof, Edgerton, V Reggie, Prof
• Format: Journal Article
• Language: English; Russian
• Published: Kidlington Elsevier Ltd 04.06.2011; Elsevier; Elsevier Limited
• Subjects: Accidents; Animal models; Case reports; case studies; Data collection; Electric Stimulation Therapy; Electrical stimuli; electrical treatment; Electrodes; Electrodes, Implanted; Electromyography; Humans; Internal Medicine; Leg; Legs; Lumbosacral Region; Male; Motor vehicles; Movement; Muscle, Skeletal - physiopathology; National Institutes of Health; Neural networks; Paralysis; Paraplegia; Paraplegia - etiology; Paraplegia - physiopathology; Paraplegia - therapy; patients; physiological state; Plasticity (neural); Posture; Preservation; Proprioception; Recovery of function; sensation; Spinal Cord; Spinal cord injuries; Spinal Cord Injuries - complications; Spinal Cord Injuries - physiopathology; Spinal cord injury; Training; Weight-Bearing; Young Adult
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(11)60547-3

Summary Background Repeated periods of stimulation of the spinal cord and training increased the ability to control movement in animal models of spinal cord injury. We hypothesised that tonic epidural spinal cord stimulation can modulate spinal circuitry in human beings into a physiological state that enables sensory input from standing and stepping movements to serve as a source of neural control to undertake these tasks. Methods A 23-year-old man who had paraplegia from a C7–T1 subluxation as a result of a motor vehicle accident in July 2006, presented with complete loss of clinically detectable voluntary motor function and partial preservation of sensation below the T1 cord segment. After 170 locomotor training sessions over 26 months, a 16-electrode array was surgically placed on the dura (L1–S1 cord segments) in December 2009, to allow for chronic electrical stimulation. Spinal cord stimulation was done during sessions that lasted up to 250 min. We did 29 experiments and tested several stimulation combinations and parameters with the aim of the patient achieving standing and stepping. Findings Epidural stimulation enabled the man to achieve full weight-bearing standing with assistance provided only for balance for 4·25 min. The patient achieved this standing during stimulation using parameters identified as specific for standing while providing bilateral load-bearing proprioceptive input. We also noted locomotor-like patterns when stimulation parameters were optimised for stepping. Additionally, 7 months after implantation, the patient recovered supraspinal control of some leg movements, but only during epidural stimulation. Interpretation Task-specific training with epidural stimulation might reactivate previously silent spared neural circuits or promote plasticity. These interventions could be a viable clinical approach for functional recovery after severe paralysis. Funding National Institutes of Health and Christopher and Dana Reeve Foundation.