The role of lipid droplets in metabolic disease in rodents and humans

• Published in: The Journal of clinical investigation Vol. 121; no. 6; pp. 2102 - 2110
• Main Authors: Greenberg, Andrew S, Coleman, Rosalind A, Kraemer, Fredric B, McManaman, James L, Obin, Martin S, Puri, Vishwajeet, Yan, Qing-Wu, Miyoshi, Hideaki, Mashek, Douglas G
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.06.2011
• Subjects: Adipocytes; Adipocytes - physiology; Adipocytes - ultrastructure; Adipose Tissue - physiopathology; Animals; Biology; Biomedical research; Biosynthesis; Blood lipids; Cell death; Cholesterol; Diabetes; Diabetes Mellitus - physiopathology; Disease; Energy Metabolism - physiology; Enzymes; Fatty acids; Fatty Acids - adverse effects; Fatty Acids - metabolism; Fatty Liver - physiopathology; Fibroblasts; Glycerol; Humans; Hydrolysis; Insulin Resistance; Intracellular Signaling Peptides and Proteins - physiology; Lipids; Lipids - physiology; Lipolysis - physiology; Metabolic Diseases - physiopathology; Metabolic disorders; Mice; Mice, Mutant Strains; Muscle, Skeletal - metabolism; Non-alcoholic Fatty Liver Disease; Obesity - physiopathology; Physiology; Proteins; Review; Signal Transduction - physiology; Triglycerides; Triglycerides - metabolism; Vacuoles - physiology

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates...