The role of lipid droplets in metabolic disease in rodents and humans

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates...

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Published inThe Journal of clinical investigation Vol. 121; no. 6; pp. 2102 - 2110
Main Authors Greenberg, Andrew S, Coleman, Rosalind A, Kraemer, Fredric B, McManaman, James L, Obin, Martin S, Puri, Vishwajeet, Yan, Qing-Wu, Miyoshi, Hideaki, Mashek, Douglas G
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.06.2011
Subjects
Adipocytes
Adipocytes - physiology
Adipocytes - ultrastructure
Adipose Tissue - physiopathology
Animals
Biology
Biomedical research
Biosynthesis
Blood lipids
Cell death
Cholesterol
Diabetes
Diabetes Mellitus - physiopathology
Disease
Energy Metabolism - physiology
Enzymes
Fatty acids
Fatty Acids - adverse effects
Fatty Acids - metabolism
Fatty Liver - physiopathology
Fibroblasts
Glycerol
Humans
Hydrolysis
Insulin Resistance
Intracellular Signaling Peptides and Proteins - physiology
Lipids
Lipids - physiology
Lipolysis - physiology
Metabolic Diseases - physiopathology
Metabolic disorders
Mice
Mice, Mutant Strains
Muscle, Skeletal - metabolism
Non-alcoholic Fatty Liver Disease
Obesity - physiopathology
Physiology
Proteins
Review
Signal Transduction - physiology
Triglycerides
Triglycerides - metabolism
Vacuoles - physiology
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Abstract Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
AbstractList Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
Audience Academic
Author McManaman, James L
Coleman, Rosalind A
Yan, Qing-Wu
Mashek, Douglas G
Greenberg, Andrew S
Obin, Martin S
Miyoshi, Hideaki
Kraemer, Fredric B
Puri, Vishwajeet
AuthorAffiliation 1 Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA. 2 Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 3 Division of Endocrinology, Stanford University; VA Palo Alto Health Care System, Palo Alto, California, USA. 4 Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado, Anschutz Medical Campus, Denver, Colorado, USA. 5 Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA. 6 Department of Internal Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 7 Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota, USA
AuthorAffiliation_xml – name: 1 Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA. 2 Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. 3 Division of Endocrinology, Stanford University; VA Palo Alto Health Care System, Palo Alto, California, USA. 4 Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado, Anschutz Medical Campus, Denver, Colorado, USA. 5 Department of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts, USA. 6 Department of Internal Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan. 7 Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota, USA
Author_xml – sequence: 1
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  surname: Greenberg
  fullname: Greenberg, Andrew S
  email: Andrew.greenberg@tufts.edu
  organization: Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA. Andrew.greenberg@tufts.edu
– sequence: 2
  givenname: Rosalind A
  surname: Coleman
  fullname: Coleman, Rosalind A
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  fullname: McManaman, James L
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  surname: Obin
  fullname: Obin, Martin S
– sequence: 6
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– sequence: 9
  givenname: Douglas G
  surname: Mashek
  fullname: Mashek, Douglas G
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21633178$$D View this record in MEDLINE/PubMed
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PublicationCentury 2000
PublicationDate 2011-Jun
2011-6-1
20110601
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  year: 2011
  text: 2011-Jun
PublicationDecade 2010
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Ann Arbor
PublicationTitle The Journal of clinical investigation
PublicationTitleAlternate J Clin Invest
PublicationYear 2011
Publisher American Society for Clinical Investigation
Publisher_xml – name: American Society for Clinical Investigation
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Snippet Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our...
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SubjectTerms Adipocytes
Adipocytes - physiology
Adipocytes - ultrastructure
Adipose Tissue - physiopathology
Animals
Biology
Biomedical research
Biosynthesis
Blood lipids
Cell death
Cholesterol
Diabetes
Diabetes Mellitus - physiopathology
Disease
Energy Metabolism - physiology
Enzymes
Fatty acids
Fatty Acids - adverse effects
Fatty Acids - metabolism
Fatty Liver - physiopathology
Fibroblasts
Glycerol
Humans
Hydrolysis
Insulin Resistance
Intracellular Signaling Peptides and Proteins - physiology
Lipids
Lipids - physiology
Lipolysis - physiology
Metabolic Diseases - physiopathology
Metabolic disorders
Mice
Mice, Mutant Strains
Muscle, Skeletal - metabolism
Non-alcoholic Fatty Liver Disease
Obesity - physiopathology
Physiology
Proteins
Review
Signal Transduction - physiology
Triglycerides
Triglycerides - metabolism
Vacuoles - physiology
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Title The role of lipid droplets in metabolic disease in rodents and humans
URI https://www.ncbi.nlm.nih.gov/pubmed/21633178
https://www.proquest.com/docview/872161834
https://pubmed.ncbi.nlm.nih.gov/PMC3104768
Volume 121
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