Formulation and Evaluation of Bosentan Pulsatile Drug Delivery System by using Press Coated Technique

In the present research work, we have designed a pulsatile formulation of Bosentan to treat High blood pressure as per the chronotherapeutic pattern of the disease. Core tablets were prepared by incorporating different concentration of disintegrants and were compressed in between different concentra...

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Published inInternational journal of pharmaceutical dosage forms and technology Vol. 15; no. 1; pp. 25 - 30
Main Authors Srikrishna, Shiva, Sadhana, Kasula, Sri S, Ramya
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 17.03.2023
Subjects
Antihypertensives
Bioavailability
Blood pressure
Cellulose
Drug delivery systems
Hypertension
Pharmaceuticals
Polymers
United States > US
Mumbai India
India
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Summary:In the present research work, we have designed a pulsatile formulation of Bosentan to treat High blood pressure as per the chronotherapeutic pattern of the disease. Core tablets were prepared by incorporating different concentration of disintegrants and were compressed in between different concentration of polymers. The core and compression coated tablets were subjected to pre-formulation, physicochemical and In-vitro drug release studies. FTIR studies revealed that there was not any chemical reaction between pure drug Bosentan and polymers. The pre and post-compressional parameters of tablets were also found to be within limits. Our optimized formulation F-6 releases Bosentan after a lag time of 2 hours and 98.01 % up to 12 hours. Formulations were stable for at least 3 months under standard long-term and accelerated storage conditions.
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ISSN:0975-234X
0975-4377
DOI:10.52711/0975-4377.2023.00005