Qualitative and Quantitative Tests on the Ingredients of Mahkota Dewa (Phaleria macrocarpa) Fruit Extract as an Alternative Therapy for Infertility in Endometriosis

Endometriosis is a gynecological disease with complaints of pain, infertility, or both, up to 35-50%. The fruit extract of Mahkota Dewa (Phaleria macrocarpa) contains antioxidants and anti-inflammatories, has anticancer prospects and is expected to have ingredients as an alternative therapy for trea...

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Published inResearch journal of pharmacy and technology Vol. 17; no. 8; pp. 3814 - 3820
Main Authors Beru Brahmana, Ivanna, Purwanto, Purwanto, Soetrisno, Soetrisno, Purwanto, Bambang, Pamungkasari, Eti Poncorini
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 26.08.2024
Subjects
Cancer
Chromatography
Endometriosis
Estrogens
Ethanol
Flavonoids
Gynecological diseases
Infertility
Natural products
Pathogenesis
Pharmacy
Phytochemicals
Steroids
Water
Yogyakarta Indonesia
Indonesia
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Summary:Endometriosis is a gynecological disease with complaints of pain, infertility, or both, up to 35-50%. The fruit extract of Mahkota Dewa (Phaleria macrocarpa) contains antioxidants and anti-inflammatories, has anticancer prospects and is expected to have ingredients as an alternative therapy for treating infertility in endometriosis. To conduct qualitative and quantitative tests on the content of Phaleria macrocarpa fruit extract, which is expected to contain substances that act as an alternative to infertility therapy in endometriosis. Mahkota Dewa (Phaleria macrocarpa) was ripened, and its seeds were extracted using 95% ethanol twice. The results of extracts 1 and 2 were combined and then examined by Thin Layer Chromatography (TLC). The research was conducted at the Pharmacognosy-Phytochemical Laboratory, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia. Qualitative test showed that 95% ethanol extract of Phaleria macrocarpa fruit contains flavonoids, alkaloids, terpenoids, and steroids. Quantitative test using Thin Layer Chromatography (TLC) method obtained a flavonoid content of 131.51-189.89µg/ml, equivalent to quercetin, in 6 repetitions, with a wavelength of 510 nm. Phaleria macrocarpa fruit contained flavonoids, alkaloids, terpenoids and steroids. The level of steroids contained in the fruit extract of Mahkota Dewa (Phaleria macrocarpa) had not been obtained in this study.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2024.00592