Epidemiology of measles cases, vaccine effectiveness, and performance towards measles elimination in The Gambia

• Published in: PloS one Vol. 16; no. 10; p. e0258961
• Main Authors: Sowe, Alieu, Njie, Mbye, Sowe, Dawda, Fofana, Sidat, Ceesay, Lamin, Camara, Yaya, Tesfaye, Brook, Bah, Samba, Bah, Alieu K, Baldeh, Abdoulie K, Dampha, Bakary D, Baldeh, Samba N, Touray, Alagie
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 21.10.2021; Public Library of Science (PLoS)
• Subjects: Control; Decision making; Drug dosages; Epidemics; Epidemiology; Estimates; Health risks; Health surveillance; Immunization; immunization coverage; Infectious Medicine; Infektionsmedicin; Measles; Measles vaccine; Medicin och hälsovetenskap; Mortality; Patient outcomes; Prevention; progress; Public health; Regions; Risk; Risk factors; Rubella; Science & Technology - Other Topics; Statistics; Vaccination; Vaccine efficacy; Vaccines; Gambia; Nairobi Kenya; Sweden; Kenya
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0258961

In 2011, member states of the World Health Organization (WHO) Africa Regional Office (AFRO) resolved to eliminate Measles by 2020. Our study aims to assess The Gambia's progress towards the set AFRO measles elimination target and highlight surveillance and immunisation gaps to better inform future measles prevention strategies. A retrospective review of measles surveillance data for the period 2011-2019, was extracted from The Gambia case-based measles surveillance database. WHO-UNICEF national coverage estimates were used for estimating national level MCV coverage. Measles post campaign coverage survey coverage estimates were used to estimate national measles campaign coverage. One hundred and twenty-five of the 863 reported suspected cases were laboratory confirmed as measles cases. More than half (53.6%) of the confirmed cases have unknown vaccination status, 24% of cases were vaccinated, 52.8% of cases occurred among males, and 72.8% cases were among urban residents. The incidence of measles cases per million population was lowest (0) in 2011-2012 and highest in 2015 and 2016 (31 and 23 respectively). The indicator for surveillance sensitivity was met in all years except in 2016 and 2019. Children aged 5-9 years (Incidence Rate Ratio-IRR = 0.6) and residents of Central River region (IRR = 0.21) had lower measles risk whilst unvaccinated (Adjusted IRR = 5.95) and those with unknown vaccination status (IRR 2.21) had higher measles risk. Vaccine effectiveness was 89.5%. The Gambia's quest to attain measles elimination status by 2020 has registered significant success but it is unlikely that all target indicators will be met. Vaccination has been very effective in preventing cases. There is variation in measles risk by health region, and it will be important to take it into account when designing prevention and control strategies. The quality of case investigations should be improved to enhance the quality of surveillance for decision making.