Conformationally Constrained ortho- Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y 1 Antagonist

• Published in: Journal of medicinal chemistry Vol. 56; no. 22; pp. 9275 - 9295
• Main Authors: Qiao, Jennifer X., Wang, Tammy C., Ruel, Réjean, Thibeault, Carl, L’Heureux, Alexandre, Schumacher, William A., Spronk, Steven A., Hiebert, Sheldon, Bouthillier, Gilles, Lloyd, John, Pi, Zulan, Schnur, Dora M., Abell, Lynn M., Hua, Ji, Price, Laura A., Liu, Eddie, Wu, Qimin, Steinbacher, Thomas E., Bostwick, Jeffrey S., Chang, Ming, Zheng, Joanna, Gao, Qi, Ma, Baoqing, McDonnell, Patricia A., Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
• Format: Journal Article
• Language: English
• Published: 27.11.2013
• ISSN: 0022-2623; 1520-4804
• DOI: 10.1021/jm4013906