Association between serum soluble corin and obesity in C hinese adults: A cross‐sectional study

• Published in: Obesity (Silver Spring, Md.) Vol. 23; no. 4; pp. 856 - 861
• Main Authors: Peng, Hao, Zhang, Qiu, Shen, Hengshan, Liu, Yan, Chao, Xiangqin, Tian, Honggang, Cai, Xiaoqin, Jin, Jianhua
• Format: Journal Article
• Language: English
• Published: 01.04.2015
• ISSN: 1930-7381; 1930-739X
• DOI: 10.1002/oby.21016

Objective Corin has been suggested to be associated with obesity by cell‐ and animal‐based studies. However, the association has not yet been studied in populations. Here, the aim was to explore the association in a general population of China. Methods This was a cross‐sectional study. Data on demographic information, lifestyle risk factors, and personal medical history were collected; body mass index, waist circumference, and blood pressures were measured; and serum corin, blood lipids, and blood glucose were determined in 2498 participants aged above 30 years. Results Log‐transformed corin correlated to body mass index ( r  = 0.197, P  < 0.001) and waist circumference ( r  = 0.289, P  < 0.001). In the risk factor‐adjusted analysis, compared with participants in the lowest quartile of serum corin, participants in the 4th quartile had significantly increased risk of prevalent overweight or obesity (OR = 2.26, 95% CI: 1.67‐3.04) and central obesity (OR = 1.74, 95% CI: 1.30‐2.34). ORs of overweight or obesity and central obesity positively and significantly increased with serum corin levels ( P for trend < 0.001). Conclusions Serum soluble corin was significantly and positively associated with obesity. Our findings suggested that serum soluble corin may be a marker or risk factor for obesity.