Design, Synthesis, Characterization and Non-steroidal Anti-Inflammatory Activity of Novel Oxazolone Derivatives

An innovative sequence of Oxazolone derivatives were synthesized via chemical reaction including Preparation of benzoyl glycine crystals and Synthesis of oxazolone derivatives. The synthesized compounds such as P- Chlorobenaldehyde, 4-Fluro benaldehyde, Cinnamaldehyde, 2-Chloro benaldehyde, and O- A...

Full description

Saved in:
Bibliographic Details
Published inAsian Journal of Pharmaceutical Research Vol. 13; no. 3; pp. 145 - 152
Main Authors Muthubhupathi, G., Selvakumar, M., Shree, S. Navi, Nisha, C., Priya, P. Sathiya, Varshini, P. A.
Format Journal Article
LanguageEnglish
Published Raipur Athena Information Solutions Pvt. Ltd 07.09.2023
Subjects
Arthritis
Atherosclerosis
Blood
Cancer
Fourier transforms
Inflammation
Nonsteroidal anti-inflammatory drugs
Pharmaceutical sciences
Sodium
Online AccessGet full text

Cover

More Information
Summary:An innovative sequence of Oxazolone derivatives were synthesized via chemical reaction including Preparation of benzoyl glycine crystals and Synthesis of oxazolone derivatives. The synthesized compounds such as P- Chlorobenaldehyde, 4-Fluro benaldehyde, Cinnamaldehyde, 2-Chloro benaldehyde, and O- Anisaldehyde were elucidated by Fourier Transform-Infra Red (FT-IR) spectrometer and showed its corresponding peaks. The in- vitro anti-inflammatory activity of synthesized compounds by protein denaturation assay exhibited very good significant anti-inflammatory activity. Additionally, the test compounds 2-Chloro benzaldehyde had nearest IC50 value to the standard diclofenac sodium when compared to all other test compounds, and demonstrated highest zone of inhibition at the low concentration used to exhibit the high potency.
ISSN:2231-5683
2231-5691
DOI:10.52711/2231-5691.2023.00028