Discovery of broflanilide, a novel insecticide

Broflanilide (1), discovered by Mitsui Chemicals Agro, Inc., has a unique chemical structure characterized as a meta-diamide and exhibits high activity against various pests, including Lepidopteran, Coleopteran, and Thysanopteran pests. Because broflanilide has a novel mode of action, the Insecticid...

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Bibliographic Details
Published inJournal of Pesticide Science Vol. 44; no. 2; pp. 120 - 128
Main Authors Katsuta, Hiroyuki, Nomura, Michikazu, Wakita, Takeo, Daido, Hidenori, Kobayashi, Yumi, Kawahara, Atsuko, Banba, Shinichi
Format Journal Article
LanguageEnglish
Published Japan Pesticide Science Society of Japan 20.05.2019
Japan Science and Technology Agency
Subjects
Benzene
broflanilide
insecticide
Insecticide resistance
Insecticides
Lead
Lead compounds
Lepidopteran pests
Meta-diamide
MIE-1209FL
Mode of action
Optimization
Organic chemistry
Original
Pesticide resistance
Pests
Meta-diamide
insecticide
broflanilide
MIE-1209FL
Lepidopteran pests
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Summary:Broflanilide (1), discovered by Mitsui Chemicals Agro, Inc., has a unique chemical structure characterized as a meta-diamide and exhibits high activity against various pests, including Lepidopteran, Coleopteran, and Thysanopteran pests. Because broflanilide has a novel mode of action, the Insecticide Resistance Action Committee (IRAC) categorized it as a member of a new group: Group 30. The meta-diamide structure was generated via drastic structural modification of a lead compound, flubendiamide (2), and the subsequent structural optimization of meta-diamides on each of its three benzene rings led to the discovery of broflanilide. In the present study, the details of the generation of meta-diamides from the lead compound and the structural optimization of meta-diamides are described.
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ISSN:1348-589X
1349-0923
DOI:10.1584/jpestics.D18-088