Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets

The goal of islet transplantation in human diabetes is to maintain the islet grafts in the recipients without the use of immunosuppression. One approach is to encapsulate the donor islets in permselective membranes. Hollow fibers fabricated from an acrylic copolymer were used to encapsulate small nu...

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Published inScience (American Association for the Advancement of Science) Vol. 254; no. 5039; pp. 1782 - 1784
Main Authors Lacy, Paul E., Hegre, Orion D., Gerasimidi-Vazeou, Andriani, Gentile, Frank T., Dionne, Keith E.
Format Journal Article
LanguageEnglish
Published United States American Society for the Advancement of Science 20.12.1991
American Association for the Advancement of Science
The American Association for the Advancement of Science
Subjects
Acrylic fibers
Acrylic Resins
Alginates
Animals
Animals, Newborn
Biocompatibility
Blood
Blood Glucose - metabolism
Collagens
Copolymers
Diabetes
Diabetes complications
Diabetes mellitus
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - surgery
Health care
Heterologous transplantation
In Vitro Techniques
Insulin - metabolism
Insulin Secretion
Islets of Langerhans - metabolism
Islets of Langerhans Transplantation - physiology
Male
Membranes, Artificial
Mice
Mice, Inbred C57BL
Pancreas
Pancreas transplantation
Polyvinyl Chloride
Rats
Rats, Inbred WF
Rodents
Time Factors
Transplantation
Transplantation, Heterologous
Transplants & implants
Type 1 diabetes mellitus
Type 2 diabetes mellitus
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Summary:The goal of islet transplantation in human diabetes is to maintain the islet grafts in the recipients without the use of immunosuppression. One approach is to encapsulate the donor islets in permselective membranes. Hollow fibers fabricated from an acrylic copolymer were used to encapsulate small numbers of rat islets that were immobilized in an alginate hydrogel for transplantation in diabetic mice. The fibers were biocompatible, prevented rejection, and maintained normoglycemia when transplanted intraperitoneally; hyperglycemia returned when the fibers were removed at 60 days. Normoglycemia was also maintained by subcutaneous implants that had an appropriately constructed outer surface on the fibers.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.1763328