Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain

• Published in: Diabetes (New York, N.Y.) Vol. 52; no. 8; pp. 2097 - 2101
• Main Authors: ENGSTRÖM, Gunnar, HEDBLAD, Bo, STAVENOW, Lars, LIND, Peter, JANZON, Lars, LINDGÄRDE, Folke
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.08.2003
• Subjects: Adult; Alcohol; alpha 1-Antitrypsin - metabolism; Biological and medical sciences; Blood pressure; Blood proteins; Cardiovascular disease; Cardiovascular diseases; Ceruloplasmin - metabolism; Clinical Medicine; Cohort Studies; Cross-Sectional Studies; Demographic aspects; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinology and Diabetes; Endocrinopathies; Endokrinologi och diabetes; Fibrinogen - metabolism; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Glucose; Haptoglobins - metabolism; Hemodynamics. Rheology; Homeostasis; Humans; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation - epidemiology; Insulin resistance; Klinisk medicin; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Metabolic syndrome; Middle Aged; Obesity; Obesity - blood; Obesity - diagnosis; Obesity - epidemiology; Orosomucoid - metabolism; Physiological aspects; Plasma; Predictive Value of Tests; Proteins; Questionnaires; Risk Factors; Statistics; Tumor necrosis factor-TNF; Vertebrates: cardiovascular system; Weight gain; Weight Gain - physiology; Sweden; Endocrinopathy; Inflammation; Weight gain; Diabetes mellitus; Protein
• ISSN: 0012-1797; 1939-327X; 1939-327X
• DOI: 10.2337/diabetes.52.8.2097

Inflammation-Sensitive Plasma Proteins Are Associated With Future Weight Gain Gunnar Engström 1 , Bo Hedblad 1 , Lars Stavenow 2 , Peter Lind 2 , Lars Janzon 1 and Folke Lindgärde 3 1 Department of Community Medicine, Lund University, Malmö, Sweden 2 Department of Medicine, Lund University, Malmö, Sweden 3 Department of Vascular Diseases, Lund University, Malmö, Sweden Address correspondence and reprint requests to Gunnar Engström, MD, Department of Community Medicine, Malmö University Hospital, S-20502 Malmö, Sweden. E-mail: gunnar.engstrom{at}smi.mas.lu.se Abstract Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, α1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with future weight gain. Five ISPs were measured in 2,821 nondiabetic healthy men (38–50 years of age) who were reexamined after a mean follow-up of 6.1 years. Future weight gain was studied in relation to the number of elevated ISPs (i.e., in the top quartile). The proportion with a large weight gain (75th percentile ≥3.8 kg) was 21.0, 25.9, 26.8, and 28.3%, respectively, among men with none, one, two, and three or more ISPs in the top quartile ( P for trend 0.0005). This relation remained significant after adjustments for weight at baseline, follow-up time, height (at baseline and follow-up), physical inactivity (at baseline and follow-up), smoking (at baseline and follow-up), high alcohol consumption, and insulin resistance. The relations were largely similar for all individual ISPs. Elevated ISP levels predict a large weight gain in middle-aged men. This relation could contribute to the relation between inflammation, the metabolic syndrome, and cardiovascular disease. HPA, hypothalamic-pituitary-adrenal IL, interleukin ISP, inflammation-sensitive plasma protein TNF-α, tumor necrosis factor-α Footnotes Accepted May 13, 2003. Received March 11, 2003. DIABETES