Guidelines for Intravenous Thrombolysis (Recombinant Tissue-type Plasminogen Activator), the Third Edition, March 2019: A Guideline from the Japan Stroke Society

• Published in: Neurologia medico-chirurgica Vol. 59; no. 12; pp. 449 - 491
• Main Authors: TOYODA, Kazunori, KOGA, Masatoshi, IGUCHI, Yasuyuki, ITABASHI, Ryo, INOUE, Manabu, OKADA, Yasushi, OGASAWARA, Kuniaki, TSUJINO, Akira, HASEGAWA, Yasuhiro, HATANO, Taketo, YAMAGAMI, Hiroshi, IWAMA, Toru, SHIOKAWA, Yoshiaki, TERAYAMA, Yasuo, MINEMATSU, Kazuo
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 2019; THE JAPAN NEUROSURGICAL SOCIETY; Japan Science and Technology Agency
• Subjects: acute ischemic stroke; alteplase; Guideline; Intravenous administration; Japan; Special Topic; Thrombolysis; thrombolysis; Guideline; alteplase; Japan; acute ischemic stroke
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/nmc.st.2019-0177

[Preface] In 2005, intravenous (IV) thrombolysis using alteplase, a recombinant tissue, type plasminogen activator (rt-PA), for patients with acute ischemic stroke was approved in Japanon the basis of the results of the Japan Alteplase Clinical Trial (J-ACT) with a specific low-dose regimen. Over the 10 years after approval, intravenous thrombolysis has become common as standard therapy for acute ischemic stroke. During this period, the Japan Stroke Society published the Guldlines forIntravenous Application of rt-PA (Alteplese) in 2005, independently of the Japanese Guidelines fpr the Management of Stroke in an effort to promote safe, widespread use of intravenous thrombolysis, and revised the present guidelines repeatedly according to subsequent accumulated evidence and changing therapeutic attitudes, The Japan Stroke Society also orgallized training sessions for proper use using the treatment guidelines as the textbook all over Japan every year and conducted a widespread awareness campaign. This effort was unique in Japan but was highly assessed outside Japan. Since 2018, e-learning has made it easier to participate in these training sessions.