Committed mast cell progenitors in mouse blood differ in maturity between T h1 and T h2 strains
Abstract Mast cell progenitors ( MC p) leave the bone marrow and migrate to peripheral tissues where they mature. Although the existence of committed MC p in adult mouse and human blood has been postulated, they have never been found. We have isolated a rare population of cells in adult mouse blood,...
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| Published in | Allergy (Copenhagen) Vol. 68; no. 10; pp. 1333 - 1337 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.10.2013
|
| Online Access | Get full text |
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| Summary: | Abstract
Mast cell progenitors (
MC
p) leave the bone marrow and migrate to peripheral tissues where they mature. Although the existence of committed
MC
p in adult mouse and human blood has been postulated, they have never been found. We have isolated a rare population of cells in adult mouse blood, committed to the mast cell lineage. These were identified as lineage
−
c‐kit
hi
ST
2
+
integrin β7
hi
CD
16/32
hi
cells. Moreover, a major difference in maturity of these cells based on
F
cε
RI
expression was observed between the
T
h2‐prone
BALB
/c strain and the
T
h1‐prone
C
57
BL
/6 strain (66%
vs
25% Fcε
RI
+
, respectively). Therefore, the choice of mouse strain is critical when studying disease models such as experimental asthma where mast cells and their progenitors are involved. |
|---|---|
| ISSN: | 0105-4538 1398-9995 |
| DOI: | 10.1111/all.12223 |