Solubility Enhancement of Efavirenz by Microwave Technology

In the present study, inclusion complexes of Efavirenz were developed with HPβ-cyclodextrin (HPβ-CD). The complexes were prepared by kneading method. Inclusion complexes of with HPβ-CD in aqueous solution were evaluated for phase solubility. The phase solubility diagram with the complexing agent was...

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Bibliographic Details
Published inAsian Journal of Pharmacy and Technology Vol. 14; no. 2; pp. 163 - 172
Main Author Kale, P. M.
Format Journal Article
LanguageEnglish
Published Raipur Athena Information Solutions Pvt. Ltd 01.06.2024
Subjects
Acids
Bioavailability
Clay
Dissolution
Drug dosages
Eutectics
Particle size
Permeability
Solid solutions
Solvents
Surfactants
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Summary:In the present study, inclusion complexes of Efavirenz were developed with HPβ-cyclodextrin (HPβ-CD). The complexes were prepared by kneading method. Inclusion complexes of with HPβ-CD in aqueous solution were evaluated for phase solubility. The phase solubility diagram with the complexing agent was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex. The apparent complexation constant obtained was 820M1ˉ. The drug was compatible with the polymers used. It was confirmed by fourier-transform infrared spectra. The study indicated the presence of intermolecular hydrogen bonds between and complexing agent, resulting in the formation of amorphous form. Dissolution profiles were markedly increased in inclusion complexes, compared with the drug alone and physical mixture. Moreover, the inclusion complex prepared by kneading method was shown better aqueous solubility and dissolution profile than complex prepared by physical mixture.
ISSN:2231-5705
2231-5713
DOI:10.52711/2231-5713.2024.00029