Managing a nosocomial outbreak of carbapenem‐resistant K lebsiella pneumoniae : an early A ustralian hospital experience
Abstract Background Carbapenems are traditionally reserved as the last line of defence for treatment of serious infections with multiresistant G ram‐negative bacilli. Reports of K lebsiella pneumoniae carbapenemase ( KPC )‐producing organisms have been emerging globally, but rare in A ustralasia to...
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Published in | Internal medicine journal Vol. 45; no. 10; pp. 1037 - 1043 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
01.10.2015
|
Online Access | Get full text |
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Summary: | Abstract
Background
Carbapenems are traditionally reserved as the last line of defence for treatment of serious infections with multiresistant
G
ram‐negative bacilli. Reports of
K
lebsiella pneumoniae
carbapenemase (
KPC
)‐producing organisms have been emerging globally, but rare in
A
ustralasia to date. We describe an outbreak of
KPC
‐2 producing
K
. pneumoniae
at an Australian hospital.
Methods
After initial detection in
O
ctober 2012, a retrospective review of patients with meropenem‐resistant
K
. pneumoniae
to
J
une 2012, and ongoing prospective surveillance, was undertaken. Included patients were admitted to the hospital after
J
une 2012 and had meropenem‐resistant
K
. pneumoniae
isolated from any site. Available isolates underwent detection of the
KPC
‐2 gene by polymerase chain reaction and molecular typing was performed to determine genetic relatedness between isolates. Point‐prevalence screening was performed on selected wards to detect asymptomatic carriage. Infection control procedures were implemented to contain the outbreak.
Results
Ten cases were identified in the initial cluster. Eight were localised to a single inpatient ward. Point‐prevalence screening revealed one extra case. After temporary containment, re‐emergence of
KPC
‐producing isolates was observed post
O
ctober 2013 with 18 further cases identified. Four
K
. pneumoniae
isolates in the 2012 cluster and 16 from the 2013–2014 cluster were referred for further testing. All carried the
KPC
‐2 beta‐lactamase gene. The 2012 isolates were genetically similar to the 2014 isolates.
Conclusion
KPC
‐2 mediated resistance is an emerging threat in
A
ustralia. The re‐emergence of
KPC
despite initial containment emphasises the need for constant vigilance in the microbiology laboratory and ongoing maintenance of infection control and antimicrobial stewardship activity. |
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ISSN: | 1444-0903 1445-5994 |
DOI: | 10.1111/imj.12863 |