Subspecific origin and haplotype diversity in the laboratory mouse

• Published in: Nature genetics Vol. 43; no. 7; pp. 648 - 655
• Main Authors: Churchill, Gary A, de Villena, Fernando Pardo-Manuel, Yang, Hyuna, Wang, Jeremy R, Didion, John P, Buus, Ryan J, Bell, Timothy A, Welsh, Catherine E, Bonhomme, François, Yu, Alex Hon-Tsen, Nachman, Michael W, Pialek, Jaroslav, Tucker, Priscilla, Boursot, Pierre, McMillan, Leonard
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2011; Nature Publishing Group
• Subjects: 631/1647/334/1874/345; 631/208/727/728; Agriculture; Animal Genetics and Genomics; Animals; Bacteria; Biodiversity; Bioinformatics; Biological and medical sciences; Biological diversity; Biomedical and Life Sciences; Biomedical research; Biomedicine; Cancer Research; Chromosome Mapping; Chromosomes, Mammalian - genetics; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetic diversity; Genetic Speciation; Genetic Variation; Genetics; Genetics of eukaryotes. Biological and molecular evolution; Genomes; Genotype; Genotype & phenotype; Genotypes; Haplotypes; Haplotypes - genetics; Human Genetics; Life Sciences; Mice; Mice, Inbred Strains - classification; Mice, Inbred Strains - genetics; Molecular Sequence Data; Mus musculus; Mus musculus domesticus; Phylogeny; Physiological aspects; Polymorphism, Single Nucleotide - genetics; Populations and Evolution; Rats as laboratory animals; Species Specificity; Studies; United States; Origin; Vertebrata; Mammalia; Mouse; Haplotype; Rodentia

Fernando Pardo-Manuel de Villena, Gary Churchill and colleagues provide a high-resolution phylogenetic map of mouse inbred strains based on comparisons to wild-caught mice. They show that the genomes of classical strains are overwhelmingly derived from Mus musculus domesticus whereas wild-derived la...