Prenatal Antecedents of Newborn Neurological Maturation

Fetal neurobehavioral development was modeled longitudinally using data collected at weekly intervals from 24 to 38 weeks gestation in a sample of 112 healthy pregnancies. Predictive associations between 3 measures of fetal neurobehavioral functioning and their developmental trajectories to neurolog...

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Published inChild development Vol. 81; no. 1; pp. 115 - 130
Main Authors DiPietro, Janet A., Kivlighan, Katie T., Costigan, Kathleen A., Rubin, Suzanne E., Shiffler, Dorothy E., Henderson, Janice L., Pillion, Joseph P.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.2010
Wiley-Blackwell
Subjects
Antenatal
Anxiety
Brain
Brain - growth & development
Brain - physiology
Brain stem
Child Development
Data collection
Evoked Potentials, Auditory, Brain Stem
Female
Fetal Development - physiology
Fetal Development and Early Experience
Fetal heart rate
Fetal Movement - physiology
Fetus
Fetus - physiology
Gestational Age
Heart rate
Heart Rate, Fetal - physiology
Humans
Infant Behavior - physiology
Infant, Newborn
Infants
Intervals
Longitudinal Studies
Male
Maturation
Measurement
Mental Health
Mental stress
Metabolism
Mothers
Motor ability
Motor activity
Motor Activity - physiology
Motor Reactions
Nervous System - growth & development
Neurology
Neuropsychology
Newborn babies
Newborns
Prediction
Pregnancy
Prenatal development
Psychomotor Performance - physiology
Public health
Stress Variables
Ultrasonography, Prenatal
Variability
Variance
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Summary:Fetal neurobehavioral development was modeled longitudinally using data collected at weekly intervals from 24 to 38 weeks gestation in a sample of 112 healthy pregnancies. Predictive associations between 3 measures of fetal neurobehavioral functioning and their developmental trajectories to neurological maturation in the first weeks after birth were examined. Prenatal measures included fetal heart rate (FHR) variability, fetal movement, and coupling between fetal motor activity and heart rate patterning; neonatal outcomes include a standard neurologic examination (n = 97) and brainstem auditory evoked potential (BAEP; n = 47). Optimality in newborn motor activity and reflexes was predicted by fetal motor activity, FHR variability, and somatic-cardiac coupling predicted BAEP parameters. Maternal pregnancy-specific psychological stress was associated with accelerated neurologic maturation.
Bibliography:istex:8AA70DDF45679C0F23899C2B58CD477B3D31C972
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ArticleID:CDEV1384
This research was supported by NIH/NICHD Grant R01 HD27592 to the first author. Newborn evoked potential data collection was supported by a research grant equipment loan from Intelligent Hearing Systems, Miami, FL. We thank Rafael Irizarry, Department of Biostatistics, for his contribution to the original design of the fetal protocol, and Kristen Byrnes, for her assistance with Dubowitz training and administration. We remain indebted to the diligent and generous support of our study families, without which this work would not be possible.
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ISSN:0009-3920
1467-8624
DOI:10.1111/j.1467-8624.2009.01384.x