Green synthesis of pyrido[2,1‐ a ]isoquinolines and pyrido[1,2‐ a ]quinolins using Fe 3 O 4 ‐MNPs as efficient nanocatalyst: Study of antioxidant activity

• Published in: Journal of heterocyclic chemistry Vol. 57; no. 1; pp. 337 - 345
• Main Authors: Faal Hamedani, Naghmeh, Ghazvini, Maryam, Azad, Leila, Noushin, Annataj
• Format: Journal Article
• Language: English
• Published: 01.01.2020
• ISSN: 0022-152X; 1943-5193
• DOI: 10.1002/jhet.3782

Abstract In this work, synthesis of pyrido[2,1‐ a ]isoquinolines and pyrido[1,2‐ a ]quinolins in excellent yield using multicomponent reaction of phthalaldehyde, methyl amine, methyl malonyl chloride, alkyl bromides, and triphenylphosphine in the presence of catalytic amount of Fe 3 O 4 ‐MNPs with aqueous sodium hydroxide at 80°C was investigated. The reduction of ferric chloride solution with Clover Leaf water extract caused to synthesis of magnetic iron oxide nanoparticles (Fe 3 O 4 ‐MNPs) as a green method. As well, antioxidant activity was studied for the some newly synthesized compounds such as 6a , 6c , 9b , and 9c using the DPPH radical trapping and reducing of ferric ion experiments and comparing results with synthetic antioxidants (TBHQ and BHT). As a result, compounds 6a , 6c , 9b , and 9c show good DPPH radical trapping and excellent reducing strength of ferric ion.