Carbon fluoroxide nanoparticles as fluorescent labels and sonosensitizers for theranostic applications

• Published in: Science and technology of advanced materials Vol. 16; no. 4; pp. 044601 - 44606
• Main Authors: Kharin, Alexander, Syshchyk, Olga, Geloen, Alain, Alekseev, Sergey, Rogov, Andrey, Lysenko, Vladimir, Timoshenko, Victor
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.08.2015; IOP Publishing; Taylor & Francis Ltd; National Institute for Materials Science; Taylor & Francis Group
• Subjects: bioimaging; Carbon; Feasibility; Fluorescence; Fluorescent indicators; Focus on Materials for Protection - Environment and Health; Life Sciences; luminescence; Nanoparticles; Silicon carbide; Strategy; theranostics; Therapy; Ultrasonic imaging; Ultrasonic processing; Ultrasound; theranostics; luminescence; nanoparticles; carbon; ultrasound; bioimaging; fluor; nanoparticule; nanoparticle; oxyde de carbone; ultrason; thermoluminescence; theranostic; carbon oxides; fluorine f (symbol)
• ISSN: 1468-6996; 1878-5514
• DOI: 10.1088/1468-6996/16/4/044601

Carbon fluoroxide (CFO) nanoparticles (NPs) produced from silicon carbide wafers are used as both fluorescent probes and sonosensitizers for theranostic application. In vitro cell tests were carried out to investigate the feasibility of ultrasound-based therapy with the use of the CFO NPs. The NPs that penetrated inside the cells were shown to provoke cell destruction after application of an ultrasound treatment. No significant toxic effect was observed when the cells were treated with NP concentrations up to 0.5 mg ml −1 without applying ultrasound treatment. The obtained results open a new way toward cancer therapy strategies.