Cholinesterase Inhibitory Activities of Halenaquinolsulfate from the Sponge Petrosia nigricans

The high incidence of Alzheimer’s disease (AD) required a continued exploration of promising molecules that demonstrated good affinities with the pharmacological targets of AD. This study presented cholinesterase (ChE) inhibitor screening of sponge extracts from under-explored waters, in Bali, Indon...

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Bibliographic Details
Published inResearch journal of pharmacy and technology Vol. 17; no. 7; pp. 3329 - 3333
Main Authors Mudianta, I Wayan, Parwata, I Putu, Agung Suryaputra, I Gusti Ngurah, Setiawan, Edwin, Suciati, Suciati, Hanafi, Muhammad, Carbone, Marianna
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 24.07.2024
Subjects
Alzheimer's disease
Chromatography
Enzymes
Fractions
Metabolites
Natural products
Indonesia
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Summary:The high incidence of Alzheimer’s disease (AD) required a continued exploration of promising molecules that demonstrated good affinities with the pharmacological targets of AD. This study presented cholinesterase (ChE) inhibitor screening of sponge extracts from under-explored waters, in Bali, Indonesia. The study identified ten sponges whose extracts exhibited low to high AChE inhibition percentages. One of the sponge extracts, Petrosia nigricans, displayed the highest inhibition 95.17%. Subsequent chromatographic purification of the extract returned a known pentacyclic hydroquinone, halenaquinolsulfate (HQS). This report was the first study on identifying HQS from the sponge of the genus Petrosia. Next, the compound displayed moderate acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitions with IC50values of 40.73±0.19 µg/mL and 53.12±0.32µg/mL respectively. This study expands the cholinesterase activities of the pentacyclic hydroquinone class of compounds isolated from marine sponges.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2024.00520