Functional Mapping of the Human Visual Cortex by Magnetic Resonance Imaging

Knowledge of regional cerebral hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelation between physiological function, energy metabolism, and localized blood supply. A magnetic resonance technique was developed for...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 254; no. 5032; pp. 716 - 719
Main Authors Belliveau, J. W., Kennedy, D. N., McKinstry, R. C., Buchbinder, B. R., Weisskoff, R. M., Cohen, M. S., Vevea, J. M., Brady, T. J., Rosen, B. R.
Format Journal Article
LanguageEnglish
Published United States American Society for the Advancement of Science 01.11.1991
American Association for the Advancement of Science
The American Association for the Advancement of Science
Subjects
550200 - Biochemistry
Anatomy
BASIC BIOLOGICAL SCIENCES
Blood
BLOOD FLOW
Blood Volume
BODY
BRAIN
Brain Mapping
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
Coordinate systems
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
Humans
Imaging
Magnetic resonance
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Medical research
Methods
NERVOUS SYSTEM
NMR IMAGING
ORGANS
Photic stimulation
Regional Blood Flow
Three dimensional imaging
USES
Visual cortex
Visual Cortex - anatomy & histology
Visual Cortex - blood supply
Visual Cortex - physiology
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Summary:Knowledge of regional cerebral hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelation between physiological function, energy metabolism, and localized blood supply. A magnetic resonance technique was developed for quantitative imaging of cerebral hemodynamics, allowing for measurement of regional cerebral blood volume during resting and activated cognitive states. This technique was used to generate the first functional magnetic resonance maps of human task activation, by using a visual stimulus paradigm. During photic stimulation, localized increases in blood volume (32 ± 10 percent, n = 7 subjects) were detected in the primary visual cortex. Center-of-mass coordinates and linear extents of brain activation within the plane of the calcarine fissure are reported.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.1948051