Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action

High-density lipoprotein cholesterol (HDL-C) has been identified as a powerful independent negative predictor of cardiovascular disease. The beneficial effect of HDL is largely attributable to its key role in reverse cholesterol transport, whereby excess cholesterol in the peripheral tissues is tran...

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Published inJournal of Atherosclerosis and Thrombosis Vol. 25; no. 10; pp. 985 - 993
Main Authors Nagao, Manabu, Nakajima, Hideto, Toh, Ryuji, Hirata, Ken-ichi, Ishida, Tatsuro
Format Journal Article
LanguageEnglish
Japanese
Published Japan Japan Atherosclerosis Society 01.10.2018
Subjects
Animals
Atherosclerosis - metabolism
Atherosclerosis - prevention & control
Cardioprotective effect
Cardiotonic Agents - therapeutic use
Cholesterol, HDL - metabolism
Endothelial lipase
Fatty acid
Heart failure
High-density lipoprotein
Humans
mTOR signal
Review
Heart failure
Endothelial lipase
mTOR signal
High-density lipoprotein
Fatty acid
Cardioprotective effect
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Summary:High-density lipoprotein cholesterol (HDL-C) has been identified as a powerful independent negative predictor of cardiovascular disease. The beneficial effect of HDL is largely attributable to its key role in reverse cholesterol transport, whereby excess cholesterol in the peripheral tissues is transported to the liver, reducing the atherosclerotic burden. However, mounting evidence indicates that HDL also has pleiotropic properties, such as anti-inflammatory, anti-oxidative, and vasodilatory properties, which may contribute in reducing the incidence of heart failure. Actually, previous data from clinical and experimental studies have suggested that HDL exerts cardioprotective effects irrespective of the presence/absence of coronary artery disease. This review summarizes the currently available evidence regarding beneficial effects of HDL on the heart beyond its anti-atherogenic property. Understanding the mechanisms of cardiac protection by HDL will provide new insight into the underlying mechanism and therapeutic strategy for heart failure.
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ISSN:1340-3478
1880-3873
DOI:10.5551/jat.RV17025