Psoriasis and obesity: Comorbidity or a single genetic code?

• Published in: Medicinskij sovet no. 11; pp. 114 - 121
• Main Authors: Novikova, V. P., Al Nawaiseh, Kh. Z.H., Zavyalova, A. N., Karelov, D. A., Zaslavsky, D. V., Markovskaya, I. N., Buntovskaya, A. S., Trandina, A. E., Glushakov, R. I.
• Format: Journal Article
• Language: English
• Published: 02.08.2025
• ISSN: 2079-701X; 2658-5790
• DOI: 10.21518/ms2025-219

Introduction . Psoriasis is often accompanied by obesity, insulin resistance, arterial hypertension and dyslipidemia. It is noted that the higher the PASI score, the higher the risk of obesity in patients. Aim . To study the polymorphism of the genes FADS1 rs174544, FADS1 rs174583; APOE rs769452, APOA1 rs1799837; FTO rs9939609; LIPC rs2070895 and the impact on nutritional status in children with psoriasis. Materials and methods . In a single-center, cross-sectional cohort study, gene polymorphism was studied in 45 patients, average age 14.05 years. Unified examination protocol: PASI; Antro Plus WHO, MEDASS bioimpedance. Genotyping of genomic DNA samples was performed in real time on a DT-Prime amplifier (RT-PCR). Statistical analysis StatTech v. 3.1.8. Results . PASI averaged 32.2 points. Average BMI was 22.6 kg/m 2 [20.288; 25.069], BMI Z-score was 1.706 [-0.175; 0.928]. Overweight and obesity are observed in adolescents according to weight Z-score (17.1%) and BMI (5.7%), mainly in boys. Children with obesity are characterized by CC alleles of FADS1 rs174544 and FADS1 rs174583 ; correlations with active cell mass (p = 0.034), its proportion (p = 0.013) and skeletal muscle mass (SMM) (p = 0.049). APOE rs769452 only homozygous variant Leu/ Leu occurs. In children with obesity, the CC allele of APOA1 rs1799837 is more common. The FTO rs9939609 gene was found in the AT and AA alleles in children with excess body weight and obesity. For TT carriers, the highest proportion of %SMM (p = 0.026). For %SMM (Mann-Whitney U-test), statistically significant differences were revealed (p < 0.05) between A / A and T / T (p = 0.028) A / T and T / T (p = 0.008). Conclusions . Obesity and psoriasis, having different roots, can be regulated by the same genes. However, the relationship between psoriasis and obesity in children has not been fully studied and remains the subject of research and discussion in the scientific literature.