Conscious perception of errors and its relation to the anterior insula

• Published in: Brain Structure and Function Vol. 214; no. 5-6; pp. 629 - 643
• Main Authors: Ullsperger, Markus, Harsay, Helga A., Wessel, Jan R., Ridderinkhof, K. Richard
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2010; Springer Nature B.V
• Subjects: Adaptations; Animals; Arousal; Autonomic nervous system; Autonomic Nervous System - physiology; Biomedical and Life Sciences; Biomedicine; Brain architecture; Brain research; Cell Biology; Cerebral Cortex - anatomy & histology; Cerebral Cortex - physiology; Consciousness; Consciousness - physiology; Discrimination, Psychological - physiology; Errors; Functional anatomy; Humans; Judgment - physiology; Neurology; Neurosciences; Norepinephrine; Orienting response; Perception; Perception - physiology; Perceptions; Recruitment; Review; Reviews; Structure-function relationships; ERN; Rostral cingulate zone; Error awareness; Autonomic arousal; Orienting response; Norepinephrine; Performance monitoring; Anterior insula
• ISSN: 1863-2653; 1863-2661; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-010-0261-1

To detect erroneous action outcomes is necessary for flexible adjustments and therefore a prerequisite of adaptive, goal-directed behavior. While performance monitoring has been studied intensively over two decades and a vast amount of knowledge on its functional neuroanatomy has been gathered, much less is known about conscious error perception, often referred to as error awareness. Here, we review and discuss the conditions under which error awareness occurs, its neural correlates and underlying functional neuroanatomy. We focus specifically on the anterior insula, which has been shown to be (a) reliably activated during performance monitoring and (b) modulated by error awareness. Anterior insular activity appears to be closely related to autonomic responses associated with consciously perceived errors, although the causality and directions of these relationships still needs to be unraveled. We discuss the role of the anterior insula in generating versus perceiving autonomic responses and as a key player in balancing effortful task-related and resting-state activity. We suggest that errors elicit reactions highly reminiscent of an orienting response and may thus induce the autonomic arousal needed to recruit the required mental and physical resources. We discuss the role of norepinephrine activity in eliciting sufficiently strong central and autonomic nervous responses enabling the necessary adaptation as well as conscious error perception.